We have examined TCR V beta expression in a collection of wild mice. Many of the mice were homozygous for a large deletion at the V beta locus, and many animals also suppressed expression of several V betas using self superantigens. Expression of V beta 8.2 was unexpectedly suppressed by a self superantigen in some wild mice, which was due to the presence in these animals of a variant V beta 8.2 gene. The amino acid changes in this gene product suggest contact sites between V beta and the superantigen. Although all V betas are expressed within each wild mouse population, individual mice have a limited and variable V beta repertoire. The independent origin of multiple V beta deletions and the presence of polymorphic self superantigens suggest that this variation may be maintained by balancing selection.
Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.
A M Pullen, W Potts, E K Wakeland, J Kappler, P Marrack; Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.. J Exp Med 1 January 1990; 171 (1): 49–62. doi: https://doi.org/10.1084/jem.171.1.49
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