Inducible cell adhesion molecule 110 (INCAM-110) is a 110-kD glycoprotein expressed on cytokine-activated human vascular endothelial cells. mAb blocking studies indicate that INCAM-110 and intercellular adhesion molecule 1 (ICAM-1) independently support the adhesion of lymphocytes to activated human umbilical vein endothelial cell monolayers. Anti-CD11a/CD18 antibodies with anti-INCAM-110 mAb E1/6 produce greater inhibition of lymphocyte adhesion than either reagent alone, suggesting that INCAM-110 and LFA-1 are not an obligate receptor-ligand pair. Blood monocytes, but not polymorphonuclear leukocytes, also appear to bind endothelial INCAM-110. Endothelial expression of INCAM-110 is upregulated at sites of inflammation, suggesting a role in the recruitment of mononuclear leukocytes.
Article|
April 01 1990
Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism.
G E Rice,
G E Rice
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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J M Munro,
J M Munro
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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M P Bevilacqua
M P Bevilacqua
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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G E Rice
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
J M Munro
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
M P Bevilacqua
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1990) 171 (4): 1369–1374.
Citation
G E Rice, J M Munro, M P Bevilacqua; Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism.. J Exp Med 1 April 1990; 171 (4): 1369–1374. doi: https://doi.org/10.1084/jem.171.4.1369
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