IL-1 is known to have a central role in the induction of acute-phase response, and some of its activities (including induction of some acute-phase proteins) were reported to be mediated by an induction of IL-6. Administration to rats of 200 ng of human rIL-1 by intracerebroventricular injection resulted in a more marked induction of circulating IL-6 than the same dose of IL-1 administered systemically (intravenously or intraperitoneally). Induction of serum IL-6 by centrally administered IL-1 was also observed in hypophysectomized or adrenalectomized rats, suggesting that activation of the hypothalamus-pituitary-adrenal axis is not essential for this effect of IL-1. IL-6 induction was also observed after pretreatment with indomethacin, indicating that the effect was dissociated from the pyrogenic activity of IL-1. Induction of IL-6 by a central action could represent a novel pathway in IL-1-induced acute-phase response.
Article|
May 01 1990
Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6.
M G De Simoni,
M G De Simoni
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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M Sironi,
M Sironi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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A De Luigi,
A De Luigi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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A Manfridi,
A Manfridi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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A Mantovani,
A Mantovani
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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P Ghezzi
P Ghezzi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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M G De Simoni
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
M Sironi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
A De Luigi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
A Manfridi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
A Mantovani
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
P Ghezzi
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1990) 171 (5): 1773–1778.
Citation
M G De Simoni, M Sironi, A De Luigi, A Manfridi, A Mantovani, P Ghezzi; Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6.. J Exp Med 1 May 1990; 171 (5): 1773–1778. doi: https://doi.org/10.1084/jem.171.5.1773
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