A receptor binding to the C1q subcomponent of complement has been reported by many workers. In this paper we report for the first time that C1q receptor binds not only to C1q, but also to three other structurally similar ligands, namely mannan binding protein (MBP), conglutinin, and lung surfactant protein (SP-A). All these ligands have been reported to enhance removal of species bound to their globular domain from blood (MBP, conglutinin, C1q) or lung (SP-A) through phagocytosis. One of the possible roles for ligand-receptor binding may be initiation of phagocytosis.
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September 01 1990
Human leukocyte C1q receptor binds other soluble proteins with collagen domains.
R Malhotra,
R Malhotra
Department of Biochemistry, University of Oxford, United Kingdom.
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S Thiel,
S Thiel
Department of Biochemistry, University of Oxford, United Kingdom.
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K B Reid,
K B Reid
Department of Biochemistry, University of Oxford, United Kingdom.
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R B Sim
R B Sim
Department of Biochemistry, University of Oxford, United Kingdom.
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R Malhotra
Department of Biochemistry, University of Oxford, United Kingdom.
S Thiel
Department of Biochemistry, University of Oxford, United Kingdom.
K B Reid
Department of Biochemistry, University of Oxford, United Kingdom.
R B Sim
Department of Biochemistry, University of Oxford, United Kingdom.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1990) 172 (3): 955–959.
Citation
R Malhotra, S Thiel, K B Reid, R B Sim; Human leukocyte C1q receptor binds other soluble proteins with collagen domains.. J Exp Med 1 September 1990; 172 (3): 955–959. doi: https://doi.org/10.1084/jem.172.3.955
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