Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.
Article|
November 01 1990
Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma.
C Nathan,
C Nathan
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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K Squires,
K Squires
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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W Griffo,
W Griffo
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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W Levis,
W Levis
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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M Varghese,
M Varghese
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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C K Job,
C K Job
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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A R Nusrat,
A R Nusrat
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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S Sherwin,
S Sherwin
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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S Rappoport,
S Rappoport
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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E Sanchez
E Sanchez
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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C Nathan
Department of Medicine, Cornell University Medical College, New York, New York 10021.
K Squires
Department of Medicine, Cornell University Medical College, New York, New York 10021.
W Griffo
Department of Medicine, Cornell University Medical College, New York, New York 10021.
W Levis
Department of Medicine, Cornell University Medical College, New York, New York 10021.
M Varghese
Department of Medicine, Cornell University Medical College, New York, New York 10021.
C K Job
Department of Medicine, Cornell University Medical College, New York, New York 10021.
A R Nusrat
Department of Medicine, Cornell University Medical College, New York, New York 10021.
S Sherwin
Department of Medicine, Cornell University Medical College, New York, New York 10021.
S Rappoport
Department of Medicine, Cornell University Medical College, New York, New York 10021.
E Sanchez
Department of Medicine, Cornell University Medical College, New York, New York 10021.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1990) 172 (5): 1509–1512.
Citation
C Nathan, K Squires, W Griffo, W Levis, M Varghese, C K Job, A R Nusrat, S Sherwin, S Rappoport, E Sanchez; Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma.. J Exp Med 1 November 1990; 172 (5): 1509–1512. doi: https://doi.org/10.1084/jem.172.5.1509
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