Mice with the autosomal recessive severe combined immune deficiency (scid) mutation lack mature lymphocytes because of defective joining of T cell receptor and immunoglobulin (Ig) gene segments. Penetrance of this mutation is incomplete since 10-25% of SCID mice produce some T or B lymphocytes. This "leaky" phenotype could be due to a reversion of the mutation in some mice or to a constant, low frequency of functional lymphocytes generated in all SCID mice with variable survival of such cells. We report here that all SCID mice can be stimulated to produce functional B cells by the transfer of normal neonatal, but not adult, T cells. T cell-induced rescue of C.B-17scid B cells results in high levels of Ig expressing the Ighb allotype of the SCID recipient. These results show that all SCID mice generate some functional B cells, the majority of which do not survive in the absence of a subset of T cells present in high frequency in the neonate.
Article|
January 01 1991
Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiency.
J E Riggs,
J E Riggs
Division of Immunology, Medical Biology Institute, La Jolla, California 92037.
Search for other works by this author on:
R S Stowers,
R S Stowers
Division of Immunology, Medical Biology Institute, La Jolla, California 92037.
Search for other works by this author on:
D E Mosier
D E Mosier
Division of Immunology, Medical Biology Institute, La Jolla, California 92037.
Search for other works by this author on:
J E Riggs
Division of Immunology, Medical Biology Institute, La Jolla, California 92037.
R S Stowers
Division of Immunology, Medical Biology Institute, La Jolla, California 92037.
D E Mosier
Division of Immunology, Medical Biology Institute, La Jolla, California 92037.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1991) 173 (1): 265–268.
Citation
J E Riggs, R S Stowers, D E Mosier; Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiency.. J Exp Med 1 January 1991; 173 (1): 265–268. doi: https://doi.org/10.1084/jem.173.1.265
Download citation file: