During viral infections, CD8+,CD45RO+ T populations expand. These primed cells express abundant levels of cytoplasmic granules that contain perforin and TIA-1. Recent work has suggested that the majority of this CD8+ population downregulates Bcl-2 protein expression and is destined to undergo apoptosis. In this study we have investigated the elimination of these apoptotic CD8+ T cells by both human monocyte-derived and murine bone marrow macrophages. We have found that these phagocytes recognize and ingest both apoptotic CD8+ and CD4+ T cells using an alpha v beta 3 (vitronectin receptor)/CD36/thrombospondin recognition system, with the same receptors being used in the recognition of apoptotic neutrophils. These data provide new evidence for a mechanism that enables the clearance of greatly increased populations of CD8+ effector cells which are found during viral infections. This enables cellular homeostasis to occur in the host upon resolution of viral diseases in vivo.
Article|
November 01 1994
The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections.
A N Akbar,
A N Akbar
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
J Savill,
J Savill
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
W Gombert,
W Gombert
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
M Bofill,
M Bofill
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
N J Borthwick,
N J Borthwick
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
F Whitelaw,
F Whitelaw
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
J Grundy,
J Grundy
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
G Janossy,
G Janossy
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
M Salmon
M Salmon
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Search for other works by this author on:
A N Akbar
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
J Savill
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
W Gombert
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
M Bofill
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
N J Borthwick
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
F Whitelaw
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
J Grundy
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
G Janossy
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
M Salmon
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, United Kingdom.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1994) 180 (5): 1943–1947.
Citation
A N Akbar, J Savill, W Gombert, M Bofill, N J Borthwick, F Whitelaw, J Grundy, G Janossy, M Salmon; The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections.. J Exp Med 1 November 1994; 180 (5): 1943–1947. doi: https://doi.org/10.1084/jem.180.5.1943
Download citation file: