Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce interleukin 4 (T helper [Th]2-like) or interferon-gamma (Th1-like). Using a system in which priming leads to responses dominated by one or the other of these cell types, we show that varying either the antigenic peptide or the major histocompatibility complex class II molecule can determine whether Th1-like or Th2-like responses are obtained. Our results show that peptide/major histocompatibility complex class II complexes that interact strongly with the T cell receptor favor generation of Th1-like cells, while those that bind weakly favor priming of Th2-like T cells. Thus, signals from the T cell receptor can influence the differentiation of CD4 T cells into specific types of effector cells.
Article|
April 01 1995
Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.
C Pfeiffer,
C Pfeiffer
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
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J Stein,
J Stein
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
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S Southwood,
S Southwood
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
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H Ketelaar,
H Ketelaar
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
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A Sette,
A Sette
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
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K Bottomly
K Bottomly
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
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C Pfeiffer
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
J Stein
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
S Southwood
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
H Ketelaar
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
A Sette
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
K Bottomly
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1995) 181 (4): 1569–1574.
Citation
C Pfeiffer, J Stein, S Southwood, H Ketelaar, A Sette, K Bottomly; Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.. J Exp Med 1 April 1995; 181 (4): 1569–1574. doi: https://doi.org/10.1084/jem.181.4.1569
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