Familial clustering of autoimmune thyroid diseases has led to studies of their association with human major histocompatibility complex (MHC) class II genes. One such gene implicated in Hashimoto's thyroiditis (HT) is HLA-DR3, but the association is weak and is contradicted by other reports. On the other hand, murine experimental autoimmune thyroiditis (EAT), a model for HT, presents a clear linkage with MHC class II. Moreover, it is inducible with thyroglobulin (Tg), the common autoantigen in either species. Immunization of HLA-DRB1* 0301 (DR3) transgenic mice with mouse or human Tg resulted in severe thyroiditis. In contrast, transgenic mice expressing the HLA-DRB1*1502 (DR2) gene were resistant to EAT. Our studies show that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen.
Article|
September 01 1996
HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene.
Y C Kong,
Y C Kong
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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L C Lomo,
L C Lomo
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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R W Motte,
R W Motte
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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A A Giraldo,
A A Giraldo
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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J Baisch,
J Baisch
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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G Strauss,
G Strauss
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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G J Hämmerling,
G J Hämmerling
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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C S David
C S David
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
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Y C Kong
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
L C Lomo
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
R W Motte
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
A A Giraldo
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
J Baisch
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
G Strauss
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
G J Hämmerling
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
C S David
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1996) 184 (3): 1167–1172.
Citation
Y C Kong, L C Lomo, R W Motte, A A Giraldo, J Baisch, G Strauss, G J Hämmerling, C S David; HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene.. J Exp Med 1 September 1996; 184 (3): 1167–1172. doi: https://doi.org/10.1084/jem.184.3.1167
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