It is characteristic for virus infections that monocytes/macrophages and lymphocytes infiltrate infected tissue while neutrophils are absent. To understand the mechanisms selectively attracting mononuclear cells in viral diseases, we examined in an influenza A virus model the expression and regulation of chemokines as candidate molecules responsible for the immigration of leukocytes into inflamed tissue. After influenza A virus infection of human monocytes, a rapid expression of the mononuclear cell attracting CC-chemokine genes MIP-1, MCP-1, and RANTES occurred which was followed by the release of chemokine proteins. In striking contrast to CC-chemokines, the expression of the prototype neutrophil CXC-chemoattractants IL-8 and GRO-alpha was completely suppressed after influenza A infection. The release of other neutrophil chemotactic factors was excluded by microchemotaxis assays. These results suggest that the virus-specific induction of mononuclear cell-attracting chemokines accounts for the preferential influx of mononuclear leukocytes into virus-infected tissue.
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September 01 1996
Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection.
H Sprenger,
H Sprenger
Institute of Immunology, Philipps-University Marburg, Germany.
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R G Meyer,
R G Meyer
Institute of Immunology, Philipps-University Marburg, Germany.
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A Kaufmann,
A Kaufmann
Institute of Immunology, Philipps-University Marburg, Germany.
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D Bussfeld,
D Bussfeld
Institute of Immunology, Philipps-University Marburg, Germany.
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E Rischkowsky,
E Rischkowsky
Institute of Immunology, Philipps-University Marburg, Germany.
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D Gemsa
D Gemsa
Institute of Immunology, Philipps-University Marburg, Germany.
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H Sprenger
Institute of Immunology, Philipps-University Marburg, Germany.
R G Meyer
Institute of Immunology, Philipps-University Marburg, Germany.
A Kaufmann
Institute of Immunology, Philipps-University Marburg, Germany.
D Bussfeld
Institute of Immunology, Philipps-University Marburg, Germany.
E Rischkowsky
Institute of Immunology, Philipps-University Marburg, Germany.
D Gemsa
Institute of Immunology, Philipps-University Marburg, Germany.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1996) 184 (3): 1191–1196.
Citation
H Sprenger, R G Meyer, A Kaufmann, D Bussfeld, E Rischkowsky, D Gemsa; Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection.. J Exp Med 1 September 1996; 184 (3): 1191–1196. doi: https://doi.org/10.1084/jem.184.3.1191
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