Lymphocyte recognition of antigen by the antigen-specific T cell receptor (TCR) and coreceptor complexes rapidly alters the cell's adhesive properties facilitating high avidity cell-ligand interactions necessary for lymphocyte development and function. Here, we report the expression of CD81 (target of antiproliferative antigen [TAPA]-1) on human thymocytes and the physical association of CD81 with CD4 and CD8 T cell coreceptors. Antibody ligation of CD81 on thymocytes promotes the rapid induction of integrin-mediated cell-cell adhesion via lymphocyte function-associated molecule-1 (LFA-1). Cross-linking CD81 is also shown to be costimulatory with signaling through the TCR/CD3 complex inducing interleukin 2-dependent thymocyte proliferation. These data suggest that a CD81-mediated pathway in thymocytes is involved in the regulation of both cell adhesion and activation.
Article|
November 01 1996
CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation.
S C Todd,
S C Todd
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
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S G Lipps,
S G Lipps
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
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L Crisa,
L Crisa
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
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D R Salomon,
D R Salomon
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
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C D Tsoukas
C D Tsoukas
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
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S C Todd
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
S G Lipps
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
L Crisa
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
D R Salomon
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
C D Tsoukas
Department of Biology and Molecular Biology Institute, San Diego State University, California 92182-4614, USA.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1996) 184 (5): 2055–2060.
Citation
S C Todd, S G Lipps, L Crisa, D R Salomon, C D Tsoukas; CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation.. J Exp Med 1 November 1996; 184 (5): 2055–2060. doi: https://doi.org/10.1084/jem.184.5.2055
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