1. Rabbits inoculated intravenously with non-hemolytic streptococci, while under the influence of full therapeutic doses of sodium salicylate, developed almost as many inflamed joints as the untreated controls similarly inoculated.
2. The salicylated rabbits, on the other hand, had a much higher proportion of mildly inflamed Joints than did the controls.
3. This anti-inflammatory action was most evident in the animals inoculated with streptococci of the lowest virulence, and could not be demonstrated in animals inoculated with hemolytic streptococci.