The effects of specific enzyme therapy upon experimental Type III pneumococcus pneumonia in monkeys were studied by comparing the course and outcome of the disease in treated animals with that in animals which received no therapeutic aid. Enzyme treatment was found to exert a distinctly favorable influence upon the experimental pneumonia. Treatment was followed by cessation of spread of the pneumonic lesion, sterilization of the blood, and early recovery, except in animals in which the severity of the disease was extreme. While in the untreated animals a high incidence of empyema and pericarditis was observed, suppurative sequelae were apparently prevented by adequate enzyme therapy. The limitations of the therapeutic action of the specific enzyme in the presence of marked depression of the cellular reaction in infected animals are again emphasized.
Article|
May 01 1934
EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III
Thomas Francis, Jr.,
Thomas Francis, Jr.
From the Hospital of The Rockefeller Institute for Medical Research
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Edward E. Terrell,
Edward E. Terrell
From the Hospital of The Rockefeller Institute for Medical Research
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René Dubos,
René Dubos
From the Hospital of The Rockefeller Institute for Medical Research
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Oswald T. Avery
Oswald T. Avery
From the Hospital of The Rockefeller Institute for Medical Research
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Thomas Francis, Jr.
From the Hospital of The Rockefeller Institute for Medical Research
Edward E. Terrell
From the Hospital of The Rockefeller Institute for Medical Research
René Dubos
From the Hospital of The Rockefeller Institute for Medical Research
Oswald T. Avery
From the Hospital of The Rockefeller Institute for Medical Research
Received:
January 31 1934
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1934, by The Rockefeller Institute for Medical Research New York
1934
J Exp Med (1934) 59 (5): 641–667.
Article history
Received:
January 31 1934
Citation
Thomas Francis, Edward E. Terrell, René Dubos, Oswald T. Avery; EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III . J Exp Med 1 May 1934; 59 (5): 641–667. doi: https://doi.org/10.1084/jem.59.5.641
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