Neutralizing antibodies for Type 2 (Lansing) poliomyelitis virus were tested periodically in a group of 18 patients from whom Type 1 poliomyelitis virus was recovered. Data for homotypic neutralizing antibodies and Type 2 complement-fixing antibodies were also available on the majority of these patients. The results indicated that Type 2 neutralizing antibodies first appeared or significantly increased in titer in 11 of the 18 patients during the first 2 to 4 weeks after onset. In most patients the Type 2 neutralizing antibody either completely disappeared at 3 months (in one patient between 2 and 4 weeks) or dropped in titer, while the Type 1 or homotypic antibody persisted in high titer. These results are interpreted as indicating that the Type 1 and Type 2 poliomyelitis viruses share a common antigen, and that the heterotypic anti-body response is transitory while the homotypic neutralizing antibody persists for a longer time.
Article|
July 01 1952
TRANSITORY APPEARANCE OF TYPE 2 NEUTRALIZING ANTIBODY IN PATIENTS INFECTED WITH TYPE 1 POLIOMYELITIS VIRUS
Albert B. Sabin
Albert B. Sabin
From The Children's Hospital Research Foundation, University of Cincinnati, Cincinnati
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Albert B. Sabin
From The Children's Hospital Research Foundation, University of Cincinnati, Cincinnati
Received:
April 01 1952
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1952, by The Rockefeller Institute for Medical Research New York
1952
J Exp Med (1952) 96 (1): 99–106.
Article history
Received:
April 01 1952
Citation
Albert B. Sabin; TRANSITORY APPEARANCE OF TYPE 2 NEUTRALIZING ANTIBODY IN PATIENTS INFECTED WITH TYPE 1 POLIOMYELITIS VIRUS . J Exp Med 1 July 1952; 96 (1): 99–106. doi: https://doi.org/10.1084/jem.96.1.99
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