The application of methods herein described for the absorption of antibody from sera by influenza virus adsorbed to erythrocytes has greatly facilitated absorption studies with this virus and has resulted in a more comprehensive demonstration of strain differences and relationships. It is now evident that there are at least 18 different antigenic components which can be measured in Type A strains of influenza virus. Utilization of quantitative absorption technics allows the simultaneous detection of variable quantities of several different antigens so that the antigenic composite of the strain is more clearly defined than was previously possible. The wide sharing of antigenic components leads to the conclusion that no completely new antigens have formed of late nor have the antigenic components of strains isolated several years ago disappeared. Some mechanisms for antigenic variation among strains are suggested, and the significance of the variation in antigenic components is discussed in relation to specifications for an effective vaccine.
Article|
December 01 1953
THE ANTIGENIC COMPOSITION OF INFLUENZA VIRUS MEASURED BY ANTIBODY-ABSORPTION
Keith E. Jensen,
Keith E. Jensen
From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor
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Thomas Francis, Jr.
Thomas Francis, Jr.
From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor
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Keith E. Jensen
From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor
Thomas Francis, Jr.
From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor
Received:
August 13 1953
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1953, by The Rockefeller Institute for Medical Research New York
1953
J Exp Med (1953) 98 (6): 619–639.
Article history
Received:
August 13 1953
Citation
Keith E. Jensen, Thomas Francis; THE ANTIGENIC COMPOSITION OF INFLUENZA VIRUS MEASURED BY ANTIBODY-ABSORPTION . J Exp Med 1 December 1953; 98 (6): 619–639. doi: https://doi.org/10.1084/jem.98.6.619
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