Maternal diet during early gestation influences postnatal taste activity–dependent pruning by microglia
Microglia aid in refining central gustatory circuits during normal postnatal development. This process is arrested by merely restricting the mother’s dietary sodium during a limited, early prenatal period when microglia progenitors migrate from the yolk sac to the brain.
In vivo deletion in the mouse reveals an essential role of the Pax5 C-terminal domain in B cell commitment and development by activating or repressing most Pax5 target genes. This domain induces chromatin changes by interacting with chromatin-remodeling and histone-modifying complexes.
Identifying biomarkers of heterogeneity and transplantation efficacy in retinal pigment epithelial cells
This study characterizes an adult retinal pigment epithelial stem cell–derived cell product through transplantation in RCS rats and bulk and single-cell RNA sequencing, identifying distinct subpopulations and a predictive lncRNA marker (TREX) affecting cell integration and vision rescue in rats.