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Microglia aid in refining central gustatory circuits during normal postnatal development. This process is arrested by merely restricting the mother’s dietary sodium during a limited, early prenatal period when microglia progenitors migrate from the yolk sac to the brain.

In vivo deletion in the mouse reveals an essential role of the Pax5 C-terminal domain in B cell commitment and development by activating or repressing most Pax5 target genes. This domain induces chromatin changes by interacting with chromatin-remodeling and histone-modifying complexes.

This study characterizes an adult retinal pigment epithelial stem cell–derived cell product through transplantation in RCS rats and bulk and single-cell RNA sequencing, identifying distinct subpopulations and a predictive lncRNA marker (TREX) affecting cell integration and vision rescue in rats.

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