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Human neutrophils drive skin autoinflammation by releasing interleukin (IL)-26
Autoinflammation is marked by IL-1 cytokine overexpression and excessive infiltration by neutrophils. By studying pustular psoriasis, we identify a cascade where neutrophils release IL-26 and trigger skin autoinflammation. The mechanism entails IL-26 activation of keratinocytes and concurrently killing of skin microbiota with formation of IL-26–DNA complexes that stimulate TLR9.
Competitive fungal commensalism mitigates candidiasis pathology
This study reports robust competitive commensalism between fungi of the Kazachstania and Candida clades. Specifically, K. weizmannii exposure prevented C. albicans colonization of mice and caused C. albicans expulsion from the gut microbiome, mitigating systemic fungal spread and candidiasis.
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One in, one out: Commensal fungus protects against infection
In this issue of JEM, Sekeresova Kralova et al. identify a commensal yeast that displaced fungal pathogen Candida albicans and protected against subsequent invasive infections that originate from the gut.
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