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15 March 1999
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Monoclonal antibody anti-4C8 blocks transendothelial migration of T cells at the intercellular borders of HUVECs. Human T cells were cocultured with a HUVEC monolayer under conditions that would normally promote transendothelial migration of T cells. Inclusion of anti-4C8 selectively blocks the transmigration step. The result, shown by scanning electron microscopy, is that T cells adhere firmly to the monolayer surface, flatten on it, and extend pseudopods into the junctions, but are unable to migrate further. See related article in this issue by Masuyama et al., pp. 979–989.
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ISSN 0022-1007
EISSN 1540-9538
In this Issue
Article
Characterization of the 4C8 Antigen Involved in Transendothelial Migration of CD26hi T Cells after Tight Adhesion to Human Umbilical Vein Endothelial Cell Monolayers
Jun-ichi Masuyama,Taku Yoshio,Kenichi Suzuki,Seiichi Kitagawa,Masahiro Iwamoto,Takeshi Kamimura,Daisuke Hirata,Akira Takeda,Shogo Kano,Seiji Minota
Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
Xia Jin,Daniel E. Bauer,Sarah E. Tuttleton,Sharon Lewin,Agegnehu Gettie,James Blanchard,Craig E. Irwin,Jeffrey T. Safrit,John Mittler,Leor Weinberger,Leondios G. Kostrikis,Linqi Zhang,Alan S. Perelson,David D. Ho
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