-
Cover Image
Cover Image
ON THE COVER
Croci et al. find that hypoxia drives expression of the regulatory lectin galectin-1 in Kaposi's sarcoma lesions and that blocking galectin-1 inhibits hypoxia-driven angiogenesis and tumor growth. Image shows galectin-1 (red) expression in low-oxygen (green) regions of a Kaposi's sarcoma lesion. Artwork by New York-based artist Emilie Clark (emilie@emileclark.com).
See page 1985 - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Minireview
TRAIL: not just for tumors anymore?
Ware and Benedict discuss the pros and cons of TRAIL signaling in the context of bacterial infection and vascular disease.
Brief Definitive Report
Human lymphoma mutations reveal CARD11 as the switch between self-antigen–induced B cell death or proliferation and autoantibody production
CARD11 signaling determines whether antigen stimulation induces B cells to proliferate or die.
Article
Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
Genetic deletion of TRAIL or antibody blockade prevents the development of pulmonary arterial hypertension and can reverse vascular remodeling in established disease.
TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice
Neutrophil-derived TRAIL induces apoptosis of alveolar macrophages, limiting the spread of S. pneumoniae infection.
TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation
TRPC6-dependent Ca2+ flux in endothelial cells after TLR4-induced diacylglycerol production mediates lung endothelial barrier disruption and inflammation induced by LPS.
Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
An evolutionary and functional analysis of mammalian AIM2-like receptors reveals remarkable diversity and redundancy.
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma
Disrupting Gal-1 interactions with N-glycans prevents hypoxia-driven angiogenesis to suppress tumorigenesis of Kaposi’s sarcoma
Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth
Neuropilin 1 mediates anti-tumor control by promoting regulatory T cell infiltration.
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models
A CBFA2T3-GLIS2 fusion gene was identified in 31% of non–Down syndrome AMKL.
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis
Axl expression is induced by TGF-β1 during Langerhans cell differentiation and enhances apoptotic cell uptake and blocks proinflammatory cytokine production.
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
Transcriptional activator Oct2 and cofactor OBF-1 regulate B cell IL-6 to induce T cell production of IL-21, to support Tfh cell development in antiviral immunity.
Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
Both deletion and anergy shape B cell tolerance to membrane-bound antigens.
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory
B cell memory is generated along two fundamentally distinct cellular differentiation pathways.
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype
OX40 engagement induces a cytotoxic CD4+ T cell subpopulation to eradicate advance melanomas
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation
Tryptophan hydroxylase deficiency in mast cells breaks allograft tolerance, induces tumor remission, and intensifies neuroinflammation.
