Brief Definitive Report
Healthy, uninfected individuals harbor HIV-specific naive and memory CD4+ T cells, and many memory T cell epitopes are similar in sequence to peptides expressed by natural commensal bacteria, suggesting potential cross-reactivity.
Rapid eosinophil accumulation around nematode species occurs via leukotriene induction, which is necessary for nematode-induced eosinophil accumulation in the lung.
Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection
NK cells lacking proapoptotic factor Bim show impaired contraction phase after MCMV infection, leading to impaired memory cell maturation and a less effective responses to viral rechallenge.
Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers
S1PR2 and CXCR5 cooperatively regulate localization of Tfh cells in GCs to support GC responses.
Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF
Adherent neutrophils responding to chemoattractants release TNF in proximity of endothelial cell junctions to mediate microvascular leakage.
Independent of its known role in NF-κB transcription, the HOIL-1L containing LUBAC is required for assembly and activation of the NLRP3 inflammasome via linear ubiquitination of ASC.
First case of a human RASGRP2 mutation affecting Rap1 activation in platelets and causing severe bleeding.
CD1c self-reactive T cells recognize a novel class of self-lipids that are accumulated on leukemia cells.
Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy
CDK4 activation/RB phosphorylation occurs in 50% of indolent but high-risk follicular lymphomas and implies susceptibility to dual CDK4 and BCL2 inhibition.
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ
IFN-γ directly triggers degranulation and death of Paneth cells, which do not respond to microbial stimulation in primary culture.
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation
DOCK5 is a key signaling adaptor that orchestrates remodeling of the microtubule network essential for mast cell degranulation.
Agonistic anti–4-1BB suppresses autoimmune and allergic inflammation via binding to Galectin-9, which facilitates 4-1BB aggregation, signaling, and functional activity.
IL-17A stimulates cardiac fibroblasts to produce inflammatory mediators critical for the recruitment and differentiation of myeloid cells during inflammatory dilated cardiomyopathy.
CNS myelin induces regulatory functions of DC-SIGN–expressing, antigen-presenting cells via cognate interaction with MOG
Human myelin oligodendrocyte glycoprotein is decorated with fucosylated N-glycans that are recognized by DC-SIGN+ DCs and microglia that control immune homeostasis.
β2 Integrin–mediated systemic release of neutrophil extracellular traps is a novel mechanism of immunopathology associated with hantavirus infection.