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E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex

Tejas Kadakia, Xuguang Tai, Michael Kruhlak, Jan Wisniewski, Il-Young Hwang, Sumedha Roy, Terry I. Guinter, Amala Alag, John H. Kehrl, Yuan Zhuang, Alfred Singer

J Exp Med (2019) 216 (8): 1749–1761.

DOI: https://doi.org/10.1084/jem.20182285

Published: 14 June 2019

View article titled, E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex

Includes: Supplementary data

Journal Articles

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

Tom M. McCaughtry, Ruth Etzensperger, Amala Alag, Xuguang Tai, Sema Kurtulus, Jung-Hyun Park, Alex Grinberg, Paul Love, Lionel Feigenbaum, Batu Erman, Alfred Singer

J Exp Med (2012) 209 (12): 2263–2276.

DOI: https://doi.org/10.1084/jem.20121505

Published: 29 October 2012

View article titled, Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

Includes: Supplementary data

Journal Articles

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

Qing Yu, Jung-Hyun Park, Loretta L. Doan, Batu Erman, Lionel Feigenbaum, Alfred Singer

J Exp Med (2006) 203 (1): 165–175.

DOI: https://doi.org/10.1084/jem.20051836

Published: 03 January 2006

View article titled, Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

Journal Articles

IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt : Impact on Thymocyte Development

Qing Yu, Batu Erman, Jung-Hyun Park, Lionel Feigenbaum, Alfred Singer

J Exp Med (2004) 200 (6): 797–803.

DOI: https://doi.org/10.1084/jem.20032183

Published: 13 September 2004

View article titled, IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt : Impact on Thymocyte Development

Journal Articles

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

Batu Erman, Terry I. Guinter, Alfred Singer

J Exp Med (2004) 199 (12): 1719–1724.

DOI: https://doi.org/10.1084/jem.20032204

Published: 21 June 2004

View article titled, Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

Journal Articles

Unraveling a Revealing Paradox : Why Major Histocompatibility Complex I–signaled Thymocytes “Paradoxically” Appear as CD4⁺8^lo Transitional Cells During Positive Selection of CD8⁺ T Cells

Remy Bosselut, Terry I. Guinter, Susan O. Sharrow, Alfred Singer

J Exp Med (2003) 197 (12): 1709–1719.

DOI: https://doi.org/10.1084/jem.20030170

Published: 16 June 2003

View article titled, Unraveling a Revealing Paradox : Why Major Histocompatibility Complex I–signaled Thymocytes “Paradoxically” Appear as CD4+8lo Transitional Cells During Positive Selection of CD8+ T Cells

Journal Articles

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8⁺ T Cells

Qing Yu, Batu Erman, Avinash Bhandoola, Susan O. Sharrow, Alfred Singer

J Exp Med (2003) 197 (4): 475–487.

DOI: https://doi.org/10.1084/jem.20021765

Published: 17 February 2003

View article titled, In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells

Journal Articles

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks

Avinash Bhandoola, Benjamin Dolnick, Nihal Fayad, Andre Nussenzweig, Alfred Singer

J Exp Med (2000) 192 (6): 891–898.

DOI: https://doi.org/10.1084/jem.192.6.891

Published: 18 September 2000

View article titled, Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks

Journal Articles

Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

Rémy Bosselut, Weiguo Zhang, Jennifer M. Ashe, Jeffrey L. Kopacz, Lawrence E. Samelson, Alfred Singer

J Exp Med (1999) 190 (10): 1517–1526.

DOI: https://doi.org/10.1084/jem.190.10.1517

Published: 15 November 1999

View article titled, Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

Journal Articles

ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4⁺8⁺ Thymocytes with Limiting p56^lck

Jennifer M. Ashe, David L. Wiest, Ryo Abe, Alfred Singer

J Exp Med (1999) 189 (7): 1163–1168.

DOI: https://doi.org/10.1084/jem.189.7.1163

Published: 05 April 1999

View article titled, ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4+8+ Thymocytes with Limiting p56lck

Journal Articles

T Cell Receptor (TCR)-induced Death of Immature CD4⁺CD8⁺ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus

Jennifer A. Punt, Wendy Havran, Ryo Abe, Apurva Sarin, Alfred Singer

J Exp Med (1997) 186 (11): 1911–1922.

DOI: https://doi.org/10.1084/jem.186.11.1911

Published: 01 December 1997

View article titled, T Cell Receptor (TCR)-induced Death of Immature CD4+CD8+ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus

Journal Articles

Commitment of Immature CD4⁺8⁺ Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains

Harumi Suzuki, Yoichi Shinkai, Lawrence G. Granger, Frederick W. Alt, Paul E. Love, Alfred Singer

J Exp Med (1997) 186 (1): 17–23.

DOI: https://doi.org/10.1084/jem.186.1.17

Published: 07 July 1997

View article titled, Commitment of Immature CD4+8+ Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains

Journal Articles

Lineage Commitment in the Thymus: Only the Most Differentiated (TCR^hibcl-2^hi) Subset of CD4⁺CD8⁺Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

Jennifer A. Punt, Harumi Suzuki, Larry G. Granger, Susan O. Sharrow, Alfred Singer

J Exp Med (1996) 184 (6): 2091–2100.

DOI: https://doi.org/10.1084/jem.184.6.2091

Published: 01 December 1996

View article titled, Lineage Commitment in the Thymus: Only the Most Differentiated (TCRhibcl-2hi) Subset of CD4+CD8+Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

NARROW

E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt : Impact on Thymocyte Development

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

Unraveling a Revealing Paradox : Why Major Histocompatibility Complex I–signaled Thymocytes “Paradoxically” Appear as CD4⁺8^lo Transitional Cells During Positive Selection of CD8⁺ T Cells

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8⁺ T Cells

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks

Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4⁺8⁺ Thymocytes with Limiting p56^lck

T Cell Receptor (TCR)-induced Death of Immature CD4⁺CD8⁺ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus

Commitment of Immature CD4⁺8⁺ Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains

Lineage Commitment in the Thymus: Only the Most Differentiated (TCR^hibcl-2^hi) Subset of CD4⁺CD8⁺Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

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