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Clifford A. Lowell
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Journal Articles

Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models

Krisztina Futosi, Tamás Németh, Ádám I. Horváth, Clare L. Abram, Simon Tusnády, Clifford A. Lowell, Zsuzsanna Helyes, Attila Mócsai
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (7): e20221010.
https://doi.org/10.1084/jem.20221010
Published: 19 April 2023
View article titled, Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models
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Includes: Supplementary data
Journal Articles

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

Miklós Kovács, Tamás Németh, Zoltán Jakus, Cassian Sitaru, Edina Simon, Krisztina Futosi, Bálint Botz, Zsuzsanna Helyes, Clifford A. Lowell, Attila Mócsai
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (10): 1993–2011.
https://doi.org/10.1084/jem.20132496
Published: 15 September 2014
View article titled, The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment
Open the PDF for The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment in another window
Includes: Supplementary data
Journal Articles

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury

Helena Block, Jan M. Herter, Jan Rossaint, Anika Stadtmann, Stefanie Kliche, Clifford A. Lowell, Alexander Zarbock
Journal: Journal of Experimental Medicine
J Exp Med (2012) 209 (2): 407–421.
https://doi.org/10.1084/jem.20111493
Published: 30 January 2012
View article titled, Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury
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Journal Articles

Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

Patrizia Scapini, Yongmei Hu, Ching-Liang Chu, Thi-Sau Migone, Anthony L. DeFranco, Marco A. Cassatella, Clifford A. Lowell
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (8): 1757–1773.
https://doi.org/10.1084/jem.20100086
Published: 12 July 2010
View article titled, Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
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Includes: Supplementary data
Journal Articles

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

Alexander Zarbock, Clare L. Abram, Matthias Hundt, Amnon Altman, Clifford A. Lowell, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (10): 2339–2347.
https://doi.org/10.1084/jem.20072660
Published: 15 September 2008
View article titled, PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling
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Includes: Supplementary data
Journal Articles

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia

Xiang Xu, Dongji Zhang, Hong Zhang, Paul J. Wolters, Nigel P. Killeen, Brandon M. Sullivan, Richard M. Locksley, Clifford A. Lowell, George H. Caughey
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (13): 2907–2917.
https://doi.org/10.1084/jem.20061232
Published: 11 December 2006
View article titled, Neutrophil histamine contributes to inflammation in mycoplasma pneumonia
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Journal Articles

Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn

Cheryl J. Fitzer-Attas, Malcolm Lowry, Mary T. Crowley, Alexander J. Finn, Fanying Meng, Anthony L. DeFranco, Clifford A. Lowell
Journal: Journal of Experimental Medicine
J Exp Med (2000) 191 (4): 669–682.
https://doi.org/10.1084/jem.191.4.669
Published: 21 February 2000
View article titled, Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn
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Journal Articles

Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr

Hattie D. Gresham, Benjamin M. Dale, Jeffrey W. Potter, Peter W. Chang, Charlotte M. Vines, Clifford A. Lowell, Carl F. Lagenaur, Cheryl L. Willman
Journal: Journal of Experimental Medicine
J Exp Med (2000) 191 (3): 515–528.
https://doi.org/10.1084/jem.191.3.515
Published: 07 February 2000
View article titled, Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr
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Journal Articles

Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways

Anne B. Satterthwaite, Clifford A. Lowell, Wasif N. Khan, Paschalis Sideras, Frederick W. Alt, Owen N. Witte
Journal: Journal of Experimental Medicine
J Exp Med (1998) 188 (5): 833–844.
https://doi.org/10.1084/jem.188.5.833
Published: 07 September 1998
View article titled, Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways
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Journal Articles

The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105

Vivien W.F. Chan, Ingrid Mecklenbräuker, I-hsin Su, Gemma Texido, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, Alexander Tarakhovsky
Journal: Journal of Experimental Medicine
J Exp Med (1998) 188 (1): 93–101.
https://doi.org/10.1084/jem.188.1.93
Published: 01 July 1998
View article titled, The Molecular Mechanism of B Cell Activation by <em>toll</em>-like Receptor Protein RP-105
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Journal Articles

Lipopolysaccharide (LPS)-induced Macrophage Activation and Signal Transduction in the Absence of Src-Family Kinases Hck, Fgr, and Lyn

Fanying Meng, Clifford A. Lowell
Journal: Journal of Experimental Medicine
J Exp Med (1997) 185 (9): 1661–1670.
https://doi.org/10.1084/jem.185.9.1661
Published: 05 May 1997
View article titled, Lipopolysaccharide (LPS)-induced Macrophage Activation and Signal Transduction in the Absence of Src-Family Kinases Hck, Fgr, and Lyn
Open the PDF for Lipopolysaccharide (LPS)-induced Macrophage Activation and Signal Transduction in the Absence of Src-Family Kinases Hck, Fgr, and Lyn in another window