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Heinz Jacobs
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Journal Articles

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

Cesare Lancini, Paul C.M. van den Berk, Joseph H.A. Vissers, Gaetano Gargiulo, Ji-Ying Song, Danielle Hulsman, Michela Serresi, Ellen Tanger, Marleen Blom, Conchita Vens, Maarten van Lohuizen, Heinz Jacobs, Elisabetta Citterio
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (9): 1759–1777.
DOI: https://doi.org/10.1084/jem.20131436
Published: 11 August 2014
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Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27–CD70 pathway

Jonathan M. Coquet, Julie C. Ribot, Nikolina Bąbała, Sabine Middendorp, Gerda van der Horst, Yanling Xiao, Joana F. Neves, Diogo Fonseca-Pereira, Heinz Jacobs, Daniel J. Pennington, Bruno Silva-Santos, Jannie Borst
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (4): 715–728.
DOI: https://doi.org/10.1084/jem.20112061
Published: 01 April 2013
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Journal Articles

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation

Peter H.L. Krijger, Petra Langerak, Paul C.M. van den Berk, Heinz Jacobs
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (12): 2603–2611.
DOI: https://doi.org/10.1084/jem.20091707
Published: 09 November 2009
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Journal Articles

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

Petra Langerak, Anders O.H. Nygren, Peter H.L. Krijger, Paul C.M. van den Berk, Heinz Jacobs
Journal: Journal of Experimental Medicine
J Exp Med (2007) 204 (8): 1989–1998.
DOI: https://doi.org/10.1084/jem.20070902
Published: 30 July 2007
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Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

Jacob G. Jansen, Petra Langerak, Anastasia Tsaalbi-Shtylik, Paul van den Berk, Heinz Jacobs, Niels de Wind
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (2): 319–323.
DOI: https://doi.org/10.1084/jem.20052227
Published: 13 February 2006
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Includes: Supplementary data
Journal Articles

DNA Double-Strand Breaks : Prior to but not Sufficient in Targeting Hypermutation

Linda Bross, Masamichi Muramatsu, Kazuo Kinoshita, Tasuku Honjo, Heinz Jacobs
Journal: Journal of Experimental Medicine
J Exp Med (2002) 195 (9): 1187–1192.
DOI: https://doi.org/10.1084/jem.20011749
Published: 06 May 2002
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Includes: Supplementary data
Journal Articles

Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice

Heinz Jacobs, Paul Krimpenfort, Mariëlle Haks, John Allen, Bianca Blom, Corinne Démollière, Ada Kruisbeek, Hergen Spits, Anton Berns
Journal: Journal of Experimental Medicine
J Exp Med (1999) 190 (8): 1059–1068.
DOI: https://doi.org/10.1084/jem.190.8.1059
Published: 18 October 1999
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Journal Articles

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

Heinz Jacobs, Yosho Fukita, Gijsbertus T.J. van der Horst, Jan de Boer, Geert Weeda, Jeroen Essers, Niels de Wind, Bevin P. Engelward, Leona Samson, Sjef Verbeek, Josiane Ménissier de Murcia, Gilbert de Murcia, Hein t e Riele, Klaus Rajewsky
Journal: Journal of Experimental Medicine
J Exp Med (1998) 187 (11): 1735–1743.
DOI: https://doi.org/10.1084/jem.187.11.1735
Published: 01 June 1998
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