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Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Misty R. Jenkins, Jesse A. Rudd-Schmidt, Jamie A. Lopez, Kelly M. Ramsbottom, Stuart I. Mannering, Daniel M. Andrews, Ilia Voskoboinik, Joseph A. Trapani

J Exp Med (2015) 212 (3): 307–317.

DOI: https://doi.org/10.1084/jem.20140964

Published: 02 March 2015

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Includes: Supplementary data

Journal Articles

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

Nigel J. Waterhouse, Vivien R. Sutton, Karin A Sedelies, Annette Ciccone, Misty Jenkins, Stephen J. Turner, Phillip I. Bird, Joseph A. Trapani

J Exp Med (2006) 203 (4): i9.

DOI: https://doi.org/10.1084/JEM2034OIA9

Published: 17 April 2006

Journal Articles

The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene

Ilia Voskoboinik, Marie-Claude Thia, Annette De Bono, Kylie Browne, Erika Cretney, Jacob T. Jackson, Phillip K. Darcy, Stephen M. Jane, Mark J. Smyth, Joseph A. Trapani

J Exp Med (2004) 200 (6): 811–816.

DOI: https://doi.org/10.1084/jem.20040776

Published: 13 September 2004

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Journal Articles

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

Shayna E.A. Street, Joseph A. Trapani, Duncan MacGregor, Mark J. Smyth

J Exp Med (2002) 196 (1): 129–134.

DOI: https://doi.org/10.1084/jem.20020063

Published: 01 July 2002

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Includes: Supplementary data

Journal Articles

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

Vivien R. Sutton, Joanne E. Davis, Michael Cancilla, Ricky W. Johnstone, Astrid A. Ruefli, Karin Sedelies, Kylie A. Browne, Joseph A. Trapani

J Exp Med (2000) 192 (10): 1403–1414.

DOI: https://doi.org/10.1084/jem.192.10.1403

Published: 13 November 2000

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Journal Articles

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

Mark J. Smyth, Kevin Y.T. Thia, Shayna E.A. Street, Duncan MacGregor, Dale I. Godfrey, Joseph A. Trapani

J Exp Med (2000) 192 (5): 755–760.

DOI: https://doi.org/10.1084/jem.192.5.755

Published: 05 September 2000

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Journal Articles

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

Mark J. Smyth, Kevin Y. T. Thia, Shayna E.A. Street, Erika Cretney, Joseph A. Trapani, Masaru Taniguchi, Tetsu Kawano, Sonja B. Pelikan, Nadine Y. Crowe, Dale I. Godfrey

J Exp Med (2000) 191 (4): 661–668.

DOI: https://doi.org/10.1084/jem.191.4.661

Published: 21 February 2000

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Journal Articles

Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2

Sheng Wei, Ana M. Gamero, Jin Hong Liu, Angela A. Daulton, Nichola I. Valkov, Joseph A. Trapani, Andrew C. Larner, Michael J. Weber, Julie Y. Djeu

J Exp Med (1998) 187 (11): 1753–1765.

DOI: https://doi.org/10.1084/jem.187.11.1753

Published: 01 June 1998

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Journal Articles

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

Lianfa Shi, Sabine Mai, Sara Israels, Kylie Browne, Joseph A. Trapani, Arnold H. Greenberg

J Exp Med (1997) 185 (5): 855–866.

DOI: https://doi.org/10.1084/jem.185.5.855

Published: 03 March 1997

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NARROW

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

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