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Journal Articles

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

In Special Collection:

Autoimmunity: From Novel Mechanisms to Treatments

J Exp Med (2022) 220 (2): e20220386.

https://doi.org/10.1084/jem.20220386

Published: 01 December 2022

View article titled, Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

Includes: Supplementary data

Journal Articles

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Michelle S.J. Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B. Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A. Katharina Simon, Jelena S. Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J. Ishii, Cevayir Coban

J Exp Med (2021) 219 (2): e20211336.

https://doi.org/10.1084/jem.20211336

Published: 15 December 2021

View article titled, B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Includes: Supplementary data

Journal Articles

Taking regulatory T cells into medicine

Shimon Sakaguchi

J Exp Med (2021) 218 (6): e20210831.

https://doi.org/10.1084/jem.20210831

Published: 26 May 2021

View article titled, Taking regulatory T cells into medicine

Journal Articles

Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells

In Special Collection:

2020 Update on Experimental Hematology , JEM 2020 Update on Cancer Immunology and Immunotherapy

J Exp Med (2019) 217 (2): e20191009.

https://doi.org/10.1084/jem.20191009

Published: 08 November 2019

View article titled, Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells

Includes: Supplementary data

Journal Articles

Regulatory roles of IL-10–producing human follicular T cells

In Special Collection:

2019: The Year in Experimental Medicine , 2020 Germinal Centers and Immune Niches , Antibodies at the Forefront of Disease Treatment , Autoimmunity: Mechanisms and Novel Treatments

Pablo F. Cañete, Rebecca A. Sweet, Paula Gonzalez-Figueroa, Ilenia Papa, Naganari Ohkura, Holly Bolton, Jonathan A. Roco, Marta Cuenca, Katharine J. Bassett, Ismail Sayin, Emma Barry, Angel Lopez, David H. Canaday, Michael Meyer-Hermann, Claudio Doglioni, Barbara Fazekas de St Groth, Shimon Sakaguchi, Matthew C. Cook, Carola G. Vinuesa

J Exp Med (2019) 216 (8): 1843–1856.

https://doi.org/10.1084/jem.20190493

Published: 17 June 2019

View article titled, Regulatory roles of IL-10–producing human follicular T cells

Includes: Supplementary data

Journal Articles

Neuropilin 1 deficiency on CD4⁺Foxp3⁺ regulatory T cells impairs mouse melanoma growth

Wiebke Hansen, Marina Hutzler, Simone Abel, Christina Alter, Christian Stockmann, Stefanie Kliche, Juliane Albert, Tim Sparwasser, Shimon Sakaguchi, Astrid M. Westendorf, Dirk Schadendorf, Jan Buer, Iris Helfrich

J Exp Med (2012) 209 (11): 2001–2016.

https://doi.org/10.1084/jem.20111497

Published: 08 October 2012

View article titled, Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

Journal Articles

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3⁺CD25⁺CD4⁺ regulatory T cells

Kuibeom Ko, Sayuri Yamazaki, Kyoko Nakamura, Tomohisa Nishioka, Keiji Hirota, Tomoyuki Yamaguchi, Jun Shimizu, Takashi Nomura, Tsutomu Chiba, Shimon Sakaguchi

J Exp Med (2012) 209 (2): 423.

https://doi.org/10.1084/jem.200509402092c

Published: 13 February 2012

View article titled, Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

Journal Articles

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Motomu Hashimoto, Keiji Hirota, Hiroyuki Yoshitomi, Shinji Maeda, Shin Teradaira, Shuji Akizuki, Paz Prieto-Martin, Takashi Nomura, Noriko Sakaguchi, Jörg Köhl, Birgitta Heyman, Minoru Takahashi, Teizo Fujita, Tsuneyo Mimori, Shimon Sakaguchi

J Exp Med (2010) 207 (6): 1135–1143.

https://doi.org/10.1084/jem.20092301

Published: 10 May 2010

View article titled, Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Includes: Supplementary data

Journal Articles

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Keiji Hirota, Hiroyuki Yoshitomi, Motomu Hashimoto, Shinji Maeda, Shin Teradaira, Naoshi Sugimoto, Tomoyuki Yamaguchi, Takashi Nomura, Hiromu Ito, Takashi Nakamura, Noriko Sakaguchi, Shimon Sakaguchi

J Exp Med (2007) 204 (12): 2803–2812.

https://doi.org/10.1084/jem.20071397

Published: 19 November 2007

View article titled, Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Includes: Supplementary data

Journal Articles

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17⁺ Th cells that cause autoimmune arthritis

Keiji Hirota, Motomu Hashimoto, Hiroyuki Yoshitomi, Satoshi Tanaka, Takashi Nomura, Tomoyuki Yamaguchi, Yoichiro Iwakura, Noriko Sakaguchi, Shimon Sakaguchi

J Exp Med (2007) 204 (1): 41–47.

https://doi.org/10.1084/jem.20062259

Published: 16 January 2007

View article titled, T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

Includes: Supplementary data

Journal Articles

A role for Dicer in immune regulation

Bradley S. Cobb, Arnulf Hertweck, James Smith, Eric O'Connor, Daniel Graf, Terence Cook, Stephen T. Smale, Shimon Sakaguchi, Frederick J. Livesey, Amanda G. Fisher, Matthias Merkenschlager

J Exp Med (2006) 203 (11): 2519–2527.

https://doi.org/10.1084/jem.20061692

Published: 23 October 2006

View article titled, A role for Dicer in immune regulation

Includes: Supplementary data

Journal Articles

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3⁺CD25⁺CD4⁺ regulatory T cells

Kuibeom Ko, Sayuri Yamazaki, Kyoko Nakamura, Tomohisa Nishioka, Keiji Hirota, Tomoyuki Yamaguchi, Jun Shimizu, Takashi Nomura, Tsutomu Chiba, Shimon Sakaguchi

J Exp Med (2005) 202 (7): 885–891.

https://doi.org/10.1084/jem.20050940

Published: 26 September 2005

View article titled, Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells

Includes: Supplementary data

Journal Articles

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

Hiroyuki Yoshitomi, Noriko Sakaguchi, Katsuya Kobayashi, Gordon D. Brown, Tomoyuki Tagami, Toshiko Sakihama, Keiji Hirota, Satoshi Tanaka, Takashi Nomura, Ichiro Miki, Siamon Gordon, Shizuo Akira, Takashi Nakamura, Shimon Sakaguchi

J Exp Med (2005) 201 (6): 949–960.

https://doi.org/10.1084/jem.20041758

Published: 21 March 2005

View article titled, A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

Includes: Supplementary data

Journal Articles

Homeostatic maintenance of natural Foxp3⁺ CD25⁺ CD4⁺ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Ruka Setoguchi, Shohei Hori, Takeshi Takahashi, Shimon Sakaguchi

J Exp Med (2005) 201 (5): 723–735.

https://doi.org/10.1084/jem.20041982

Published: 07 March 2005

View article titled, Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Includes: Supplementary data

Journal Articles

Definition of target antigens for naturally occurring CD4⁺ CD25⁺ regulatory T cells

Hiroyoshi Nishikawa, Takuma Kato, Isao Tawara, Kanako Saito, Hiroaki Ikeda, Kagemasa Kuribayashi, Paul M. Allen, Robert D. Schreiber, Shimon Sakaguchi, Lloyd J. Old, Hiroshi Shiku

J Exp Med (2005) 201 (5): 681–686.

https://doi.org/10.1084/jem.20041959

Published: 07 March 2005

View article titled, Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

Includes: Supplementary data

Journal Articles

Erratum

Mary Jo Turk, José A. Guevara-Patiño, Gabrielle A. Rizzuto, Manuel E. Engelhorn, Shimon Sakaguchi, Alan N. Houghton

J Exp Med (2004) 201 (1): 159.

https://doi.org/10.1084/jem.20041130121404c

Published: 28 December 2004

View article titled, Erratum

Journal Articles

GITR Activation Induces an Opposite Effect on Alloreactive CD4⁺ and CD8⁺ T Cells in Graft-Versus-Host Disease

Stephanie J. Muriglan, Teresa Ramirez-Montagut, Onder Alpdogan, Thomas W. van Huystee, Jeffrey M. Eng, Vanessa M. Hubbard, Adam A. Kochman, Kartono H. Tjoe, Carlo Riccardi, Pier Paolo Pandolfi, Shimon Sakaguchi, Alan N. Houghton, Marcel R.M. van den Brink

J Exp Med (2004) 200 (2): 149–157.

https://doi.org/10.1084/jem.20040116

Published: 12 July 2004

View article titled, GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

Includes: Supplementary data

Journal Articles

Control of Immune Responses by Naturally Arising CD4⁺ Regulatory T Cells That Express Toll-like Receptors

Shimon Sakaguchi

J Exp Med (2003) 197 (4): 397–401.

https://doi.org/10.1084/jem.20030012

Published: 10 February 2003

View article titled, Control of Immune Responses by Naturally Arising CD4+ Regulatory T Cells That Express Toll-like Receptors

Journal Articles

Immunologic Self-Tolerance Maintained by Cd25⁺Cd4⁺Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Takeshi Takahashi, Tomoyuki Tagami, Sayuri Yamazaki, Toshimitsu Uede, Jun Shimizu, Noriko Sakaguchi, Tak W. Mak, Shimon Sakaguchi

J Exp Med (2000) 192 (2): 303–310.

https://doi.org/10.1084/jem.192.2.303

Published: 17 July 2000

View article titled, Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

NARROW

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Taking regulatory T cells into medicine

Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells

Regulatory roles of IL-10–producing human follicular T cells

Neuropilin 1 deficiency on CD4⁺Foxp3⁺ regulatory T cells impairs mouse melanoma growth

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3⁺CD25⁺CD4⁺ regulatory T cells

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17⁺ Th cells that cause autoimmune arthritis

A role for Dicer in immune regulation

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3⁺CD25⁺CD4⁺ regulatory T cells

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

Homeostatic maintenance of natural Foxp3⁺ CD25⁺ CD4⁺ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Definition of target antigens for naturally occurring CD4⁺ CD25⁺ regulatory T cells

Erratum

GITR Activation Induces an Opposite Effect on Alloreactive CD4⁺ and CD8⁺ T Cells in Graft-Versus-Host Disease

Control of Immune Responses by Naturally Arising CD4⁺ Regulatory T Cells That Express Toll-like Receptors

Immunologic Self-Tolerance Maintained by Cd25⁺Cd4⁺Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

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