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A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre–B Receptor Assembly

R. Wasserman, Y.-S. Li, S.A. Shinton, C.E. Carmack, T. Manser, D.L. Wiest, K. Hayakawa, R.R. Hardy

J Exp Med (1998) 187 (2): 259–264.

DOI: https://doi.org/10.1084/jem.187.2.259

Published: 19 January 1998

View article titled, A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre–B Receptor Assembly

Journal Articles

Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.

L P Casson, T Manser

J Exp Med (1995) 182 (3): 743–750.

DOI: https://doi.org/10.1084/jem.182.3.743

Published: 01 September 1995

View article titled, Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.

Journal Articles

Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.

K A Vora, T Manser

J Exp Med (1995) 181 (1): 271–281.

DOI: https://doi.org/10.1084/jem.181.1.271

Published: 01 January 1995

View article titled, Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.

Journal Articles

Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.

A M Giusti, T Manser

J Exp Med (1994) 179 (1): 235–248.

DOI: https://doi.org/10.1084/jem.179.1.235

Published: 01 January 1994

View article titled, Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.

Journal Articles

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.

A M Giusti, T Manser

J Exp Med (1993) 177 (3): 797–809.

DOI: https://doi.org/10.1084/jem.177.3.797

Published: 01 March 1993

View article titled, Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.

Journal Articles

Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype.

P Soloway, S Fish, H Passmore, M Gefter, R Coffee, T Manser

J Exp Med (1991) 174 (4): 847–858.

DOI: https://doi.org/10.1084/jem.174.4.847

Published: 01 October 1991

View article titled, Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype.

Journal Articles

Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.

S Fish, M Fleming, J Sharon, T Manser

J Exp Med (1991) 173 (3): 665–672.

DOI: https://doi.org/10.1084/jem.173.3.665

Published: 01 March 1991

View article titled, Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.

Journal Articles

Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response.

S Fish, E Zenowich, M Fleming, T Manser

J Exp Med (1989) 170 (4): 1191–1209.

DOI: https://doi.org/10.1084/jem.170.4.1191

Published: 01 October 1989

View article titled, Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response.

Journal Articles

Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.

T Manser

J Exp Med (1989) 170 (4): 1211–1230.

DOI: https://doi.org/10.1084/jem.170.4.1211

Published: 01 October 1989

View article titled, Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.

Journal Articles

Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?

T Manser, B Parhami-Seren, MN Margolies, ML Gefter

J Exp Med (1987) 166 (5): 1456–1463.

DOI: https://doi.org/10.1084/jem.166.5.1456

Published: 01 November 1987

View article titled, Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?

Journal Articles

Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.

S Fish, T Manser

J Exp Med (1987) 166 (3): 711–724.

DOI: https://doi.org/10.1084/jem.166.3.711

Published: 01 September 1987

View article titled, Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.

Journal Articles

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

Y Naparstek, J André-Schwartz, T Manser, L J Wysocki, L Breitman, B D Stollar, M Gefter, R S Schwartz

J Exp Med (1986) 164 (2): 614–626.

DOI: https://doi.org/10.1084/jem.164.2.614

Published: 01 August 1986

View article titled, A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

NARROW

A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre–B Receptor Assembly

Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.

Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.

Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.

Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype.

Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.

Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response.

Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.

Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?

Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

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