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Journal Articles

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsäter, Michael Vanlandewijck, Bojana Jakic, Eulàlia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Mäkinen
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (4): e20220741.
https://doi.org/10.1084/jem.20220741
Published: 23 January 2023
View article titled, Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
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Includes: Supplementary data
Journal Articles

Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies

In Special Collection:
Innate Immune Cells and Signaling 2023
Achraf Shamseddine, Suchit H. Patel, Valery Chavez, Zachary R. Moore, Mutayyaba Adnan, Melody Di Bona, Jun Li, Chau T. Dang, Lakshmi V. Ramanathan, Kevin C. Oeffinger, Jennifer E. Liu, Richard M. Steingart, Alessandra Piersigilli, Nicholas D. Socci, Angel T. Chan, Anthony F. Yu, Samuel F. Bakhoum, Adam M. Schmitt
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (3): e20220809.
https://doi.org/10.1084/jem.20220809
Published: 19 December 2022
View article titled, Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies
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Includes: Supplementary data
Journal Articles

Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice

Corinne M. Nielsen, Xuetao Zhang, Kunal Raygor, Shaoxun Wang, Andrew W. Bollen, Rong A. Wang
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20211390.
https://doi.org/10.1084/jem.20211390
Published: 28 November 2022
View article titled, Endothelial <em>Rbpj</em> deletion normalizes Notch4-induced brain arteriovenous malformation in mice
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Journal Articles

Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury

Hao He, Wu Yang, Nan Su, Chuankai Zhang, Jianing Dai, Feng Han, Mahak Singhal, Wenjuan Bai, Xiaolan Zhu, Jing Zhu, Zhen Liu, Wencheng Xia, Xiaoting Liu, Chonghe Zhang, Kai Jiang, Wenhui Huang, Dan Chen, Zhaoyin Wang, Xueyang He, Frank Kirchhoff, Zhenyu Li, Cong Liu, Jingning Huan, Xiaohong Wang, Wu Wei, Jing Wang, Hellmut G. Augustin, Junhao Hu
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20211422.
https://doi.org/10.1084/jem.20211422
Published: 09 November 2022
View article titled, Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury
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Includes: Supplementary data
Journal Articles

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

Corinne Hübers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Schölch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut G. Augustin, Moritz Felcht
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (1): e20202595.
https://doi.org/10.1084/jem.20202595
Published: 21 October 2022
View article titled, Primary tumor–derived systemic nANGPTL4 inhibits metastasis
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Includes: Supplementary data
Journal Articles

CARD8 makes coxsackievirus more “heartbreaking”

Qiankun Wang, Liang Shan
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (10): e20221240.
https://doi.org/10.1084/jem.20221240
Published: 21 September 2022
View article titled, CARD8 makes coxsackievirus more “heartbreaking”
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Journal Articles

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

In Special Collection:
JEM Clinical Immunology Collection 2023 , 2022: The Year in Experimental Medicine
Rhea Nadkarni, Wern Cui Chu, Cheryl Q.E. Lee, Yasir Mohamud, Lynn Yap, Gee Ann Toh, Sheryl Beh, Radiance Lim, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Kim Robinson, Karl Tryggvason, Honglin Luo, Franklin Zhong, Lena Ho
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (10): e20212117.
https://doi.org/10.1084/jem.20212117
Published: 21 September 2022
View article titled, Viral proteases activate the CARD8 inflammasome in the human cardiovascular system
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Includes: Supplementary data
Journal Articles

CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure

In Special Collection:
Fibrosis Collection 2023
Yang Zhang, Yicong Ye, Xiaoqiang Tang, Hui Wang, Toshiko Tanaka, Ran Tian, Xufei Yang, Lun Wang, Ying Xiao, Xiaomin Hu, Ye Jin, Haiyu Pang, Tian Du, Honghong Liu, Lihong Sun, Shuo Xiao, Ruijia Dong, Luigi Ferrucci, Zhuang Tian, Shuyang Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (8): e20200418.
https://doi.org/10.1084/jem.20200418
Published: 10 June 2022
View article titled, CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure
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Includes: Supplementary data
Journal Articles

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice

Tomoko Matsubara, Takahito Iga, Yuki Sugiura, Dai Kusumoto, Tsukasa Sanosaka, Ikue Tai-Nagara, Norihiko Takeda, Guo-Hua Fong, Kosei Ito, Masatsugu Ema, Hideyuki Okano, Jun Kohyama, Makoto Suematsu, Yoshiaki Kubota
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (4): e20211789.
https://doi.org/10.1084/jem.20211789
Published: 23 March 2022
View article titled, Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice
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Includes: Supplementary data
Journal Articles

Yolk sac steps up to the plate

Hanna K.A. Mikkola
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (3): e20212315.
https://doi.org/10.1084/jem.20212315
Published: 24 February 2022
View article titled, Yolk sac steps up to the plate
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Journal Articles

Vascular heterogeneity: VEGF receptors make blood vessels special

Pin Li, Napoleone Ferrara
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (3): e20212539.
https://doi.org/10.1084/jem.20212539
Published: 27 January 2022
View article titled, Vascular heterogeneity: VEGF receptors make blood vessels special
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Journal Articles

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance

In Special Collection:
Lymphatic Vessels in Health and Disease 2022
Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (3): e20210565.
https://doi.org/10.1084/jem.20210565
Published: 20 January 2022
View article titled, Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance
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Includes: Supplementary data
Journal Articles

Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation

In Special Collection:
JEM Stroke Immunology Collection 2022
Jing Li, Tripti Kumari, Andrew Barazia, Vishwanath Jha, Si-Yeon Jeong, Amber Olson, Mijeong Kim, Bum-Kyu Lee, Vijayprakash Manickam, Zhimin Song, Regina Clemens, Babak Razani, Jonghwan Kim, Mary C. Dinauer, Jaehyung Cho
Journal: Journal of Experimental Medicine
J Exp Med (2021) 219 (1): e20211083.
https://doi.org/10.1084/jem.20211083
Published: 09 November 2021
View article titled, Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation
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Includes: Supplementary data
Journal Articles

Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation

Sarah C. Huen, Andrew Wang, Kyle Feola, Reina Desrouleaux, Harding H. Luan, Richard Hogg, Cuiling Zhang, Qing-Jun Zhang, Zhi-Ping Liu, Ruslan Medzhitov
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (10): e20202151.
https://doi.org/10.1084/jem.20202151
Published: 18 August 2021
View article titled, Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation
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Journal Articles

T2B or not to B: Calming neutrophils offshore

Hafsa Munir, Theresa T. Lu
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (9): e20211407.
https://doi.org/10.1084/jem.20211407
Published: 10 August 2021
View article titled, T2B or not to B: Calming neutrophils offshore
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Journal Articles

Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair

In Special Collection:
Cardiovascular Biology 2021
Matthew DeBerge, Connor Lantz, Shirley Dehn, David P. Sullivan, Anja M. van der Laan, Hans W.M. Niessen, Margaret E. Flanagan, Daniel J. Brat, Matthew J. Feinstein, Sunjay Kaushal, Lisa D. Wilsbacher, Edward B. Thorp
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (9): e20200667.
https://doi.org/10.1084/jem.20200667
Published: 29 July 2021
View article titled, Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair
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Includes: Supplementary data
Journal Articles

Macrophage-adipocyte communication and cardiac remodeling

Gautham Yepuri, Syed Nurul Hasan, Ann Marie Schmidt, Ravichandran Ramasamy
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (9): e20211098.
https://doi.org/10.1084/jem.20211098
Published: 20 July 2021
View article titled, Macrophage-adipocyte communication and cardiac remodeling
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Journal Articles

PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice

In Special Collection:
Cardiovascular Biology 2021
Yu-Wen Cheng, Ze-Bei Zhang, Bei-Di Lan, Jing-Rong Lin, Xiao-Hui Chen, Ling-Ran Kong, Lian Xu, Cheng-Chao Ruan, Ping-Jin Gao
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (9): e20210252.
https://doi.org/10.1084/jem.20210252
Published: 08 July 2021
View article titled, PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice
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Includes: Supplementary data
Journal Articles

Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation

In Special Collection:
Cardiovascular Biology 2021 , Lymphatic Vessels in Health and Disease 2022
Jorge Arasa, Victor Collado-Diaz, Ioannis Kritikos, Jessica Danielly Medina-Sanchez, Mona Carina Friess, Elena Caroline Sigmund, Philipp Schineis, Morgan Campbell Hunter, Carlotta Tacconi, Neil Paterson, Takashi Nagasawa, Friedemann Kiefer, Taija Makinen, Michael Detmar, Markus Moser, Tim Lämmermann, Cornelia Halin
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (7): e20201413.
https://doi.org/10.1084/jem.20201413
Published: 14 May 2021
View article titled, Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation
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Journal Articles

PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling

In Special Collection:
Cardiovascular Biology 2021
Jiwen Li, Catharina Conrad, Tingting W. Mills, Nathaniel K. Berg, Boyun Kim, Wei Ruan, Jae W. Lee, Xu Zhang, Xiaoyi Yuan, Holger K. Eltzschig
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (6): e20210008.
https://doi.org/10.1084/jem.20210008
Published: 23 April 2021
View article titled, PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling
Open the PDF for PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling in another window
Includes: Supplementary data