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Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion

Yi Cai, Yejun Wang, Chenyan Shi, Youchao Dai, Fuxiang Li, Yuzhong Xu, Peize Zhang, Fanhui Kong, Guofang Deng, Zhihua Wen, Qi Zhou, Boxi Chris Kang, Amit Singhal, Qianting Yang, Carl G. Feng, Xinchun Chen

J Exp Med (2022) 219 (3): e20211777.

DOI: https://doi.org/10.1084/jem.20211777

Published: 21 January 2022

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Includes: Supplementary data

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T-independent antigen induces humoral memory through germinal centers

Xin Liu, Yongshan Zhao, Hai Qi

J Exp Med (2022) 219 (3): e20210527.

DOI: https://doi.org/10.1084/jem.20210527

Published: 12 January 2022

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How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein

Ilka Wahl, Hedda Wardemann

J Exp Med (2022) 219 (2): e20201313.

DOI: https://doi.org/10.1084/jem.20201313

Published: 10 January 2022

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Playing dirty with virus transmission

Christin Herrmann, Ken Cadwell

J Exp Med (2021) 219 (2): e20212358.

DOI: https://doi.org/10.1084/jem.20212358

Published: 28 December 2021

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Natural rodent model of viral transmission reveals biological features of virus population dynamics

Elizabeth J. Fay, Keir M. Balla, Shanley N. Roach, Frances K. Shepherd, Dira S. Putri, Talia D. Wiggen, Stephen A. Goldstein, Mark J. Pierson, Martin T. Ferris, Claire E. Thefaine, Andrew Tucker, Mark Salnikov, Valerie Cortez, Susan R. Compton, Sergei V. Kotenko, Ryan C. Hunter, David Masopust, Nels C. Elde, Ryan A. Langlois

J Exp Med (2021) 219 (2): e20211220.

DOI: https://doi.org/10.1084/jem.20211220

Published: 27 December 2021

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Includes: Supplementary data

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TIM3⁺ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16⁺ NK cells delineate MIS-C

J Exp Med (2021) 219 (2): e20211381.

DOI: https://doi.org/10.1084/jem.20211381

Published: 16 December 2021

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Human NLRP1: From the shadows to center stage

Stefan Bauernfried, Veit Hornung

J Exp Med (2021) 219 (1): e20211405.

DOI: https://doi.org/10.1084/jem.20211405

Published: 15 December 2021

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B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Michelle S.J. Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B. Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A. Katharina Simon, Jelena S. Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J. Ishii, Cevayir Coban

J Exp Med (2021) 219 (2): e20211336.

DOI: https://doi.org/10.1084/jem.20211336

Published: 15 December 2021

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Inhibitory pattern recognition receptors

Matevž Rumpret, Helen J. von Richthofen, Victor Peperzak, Linde Meyaard

J Exp Med (2021) 219 (1): e20211463.

DOI: https://doi.org/10.1084/jem.20211463

Published: 14 December 2021

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Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Kerry L. Hilligan, Sivaranjani Namasivayam, Chad S. Clancy, Danielle O’Mard, Sandra D. Oland, Shelly J. Robertson, Paul J. Baker, Ehydel Castro, Nicole L. Garza, Bernard A.P. Lafont, Reed Johnson, Franca Ronchese, Katrin D. Mayer-Barber, Sonja M. Best, Alan Sher

J Exp Med (2021) 219 (2): e20211862.

DOI: https://doi.org/10.1084/jem.20211862

Published: 10 December 2021

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Includes: Supplementary data

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Helminths make themselves at home

Elia D. Tait Wojno

J Exp Med (2021) 219 (1): e20212207.

DOI: https://doi.org/10.1084/jem.20212207

Published: 30 November 2021

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Can repurposing drugs play a role in malaria control?

Roland A. Cooper, Laura Kirkman

J Exp Med (2021) 218 (12): e20211512.

DOI: https://doi.org/10.1084/jem.20211512

Published: 22 November 2021

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Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4⁺ T cells

In Special Collection:

Immunology Update Winter 2022

Thomas Ciucci, Melanie S. Vacchio, Ting Chen, Jia Nie, Laura B. Chopp, Dorian B. McGavern, Michael C. Kelly, Rémy Bosselut

J Exp Med (2021) 219 (1): e20202343.

DOI: https://doi.org/10.1084/jem.20202343

Published: 18 November 2021

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Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products

Claire Drurey, Håvard T. Lindholm, Gillian Coakley, Marta Campillo Poveda, Stephan Löser, Rory Doolan, François Gerbe, Philippe Jay, Nicola Harris, Menno J. Oudhoff, Rick M. Maizels

J Exp Med (2021) 219 (1): e20211140.

DOI: https://doi.org/10.1084/jem.20211140

Published: 15 November 2021

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A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice

Tianyang Mao, Benjamin Israelow, Carolina Lucas, Chantal B.F. Vogels, Maria Luisa Gomez-Calvo, Olga Fedorova, Mallery I. Breban, Bridget L. Menasche, Huiping Dong, Melissa Linehan, Yale SARS-CoV-2 Genome Surveillance Initiative, Craig B. Wilen, Marie L. Landry, Nathan D. Grubaugh, Anna M. Pyle, Akiko Iwasaki

J Exp Med (2021) 219 (1): e20211818.

DOI: https://doi.org/10.1084/jem.20211818

Published: 10 November 2021

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Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis

J Exp Med (2021) 218 (12): e20211349.

DOI: https://doi.org/10.1084/jem.20211349

Published: 02 November 2021

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Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness

Stephan Isringhausen, YeVin Mun, Larisa Kovtonyuk, Nike J. Kräutler, Ute Suessbier, Alvaro Gomariz, Gianluca Spaltro, Patrick M. Helbling, Hui Chyn Wong, Takashi Nagasawa, Markus G. Manz, Annette Oxenius, César Nombela-Arrieta

J Exp Med (2021) 218 (12): e20192070.

DOI: https://doi.org/10.1084/jem.20192070

Published: 28 October 2021

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Includes: Supplementary data

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HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160

Weifeng Liu, Ting-Fang Chou, Sarah C. Garrett-Thomson, Goo-Young Seo, Elena Fedorov, Udupi A. Ramagopal, Jeffrey B. Bonanno, Qingyang Wang, Kenneth Kim, Scott J. Garforth, Kiyokazu Kakugawa, Hilde Cheroutre, Mitchell Kronenberg, Steven C. Almo

J Exp Med (2021) 218 (12): e20211112.

DOI: https://doi.org/10.1084/jem.20211112

Published: 28 October 2021

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T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM)

Hye Sun Kuehn, Jingjie Chang, Motoi Yamashita, Julie E. Niemela, Chengcheng Zou, Kazuki Okuyama, Junji Harada, Jennifer L. Stoddard, Cristiane J. Nunes-Santos, Brigette Boast, Ryan M. Baxter, Elena W.Y. Hsieh, Mary Garofalo, Thomas A. Fleisher, Tomohiro Morio, Ichiro Taniuchi, Cullen M. Dutmer, Sergio D. Rosenzweig

J Exp Med (2021) 218 (12): e20211118.

DOI: https://doi.org/10.1084/jem.20211118

Published: 25 October 2021

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Includes: Supplementary data

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Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

Eva-Maria Frickel, Christopher A. Hunter

J Exp Med (2021) 218 (11): e20201314.

DOI: https://doi.org/10.1084/jem.20201314

Published: 20 October 2021

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NARROW

Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion

T-independent antigen induces humoral memory through germinal centers

How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein

Playing dirty with virus transmission

Natural rodent model of viral transmission reveals biological features of virus population dynamics

TIM3⁺ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16⁺ NK cells delineate MIS-C

Human NLRP1: From the shadows to center stage

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Inhibitory pattern recognition receptors

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Helminths make themselves at home

Can repurposing drugs play a role in malaria control?

Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4⁺ T cells

Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products

A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice

Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis

Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160

T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

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