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Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

In Special Collection:

Hematology 2022

J Exp Med (2022) 219 (11): e20212228.

DOI: https://doi.org/10.1084/jem.20212228

Published: 02 September 2022

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Includes: Supplementary data

Journal Articles

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

In Special Collection:

Hematology 2022

Yu Rebecca Miao, Kaushik Thakkar, Can Cenik, Dadi Jiang, Kazue Mizuno, Chenjun Jia, Caiyun Grace Li, Hongjuan Zhao, Anh Diep, Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-sze Leung, Albert C. Koong, Amato J. Giaccia

J Exp Med (2022) 219 (9): e20220214.

DOI: https://doi.org/10.1084/jem.20220214

Published: 26 July 2022

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Includes: Supplementary data

Journal Articles

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

In Special Collection:

JEM Cancer Immunotherapy 2022

Alessandro Camponeschi, Kathrin Kläsener, Timothy Sundell, Christina Lundqvist, Paul T. Manna, Negar Ayoubzadeh, Martina Sundqvist, Katrin Thorarinsdottir, Mariele Gatto, Marcella Visentini, Karin Önnheim, Alaitz Aranburu, Huamei Forsman, Olov Ekwall, Linda Fogelstrand, Inger Gjertsson, Michael Reth, Inga-Lill Mårtensson

J Exp Med (2022) 219 (9): e20220201.

DOI: https://doi.org/10.1084/jem.20220201

Published: 12 July 2022

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Includes: Supplementary data

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TIRAP drives myelosuppression through an Ifnγ–Hmgb1 axis that disrupts the endothelial niche in mice

In Special Collection:

Hematology 2022

Aparna Gopal, Rawa Ibrahim, Megan Fuller, Patricia Umlandt, Jeremy Parker, Jessica Tran, Linda Chang, Joanna Wegrzyn-Woltosz, Jeffrey Lam, Jenny Li, Melody Lu, Aly Karsan

J Exp Med (2022) 219 (3): e20200731.

DOI: https://doi.org/10.1084/jem.20200731

Published: 28 January 2022

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Includes: Supplementary data

Journal Articles

Bhlhe40 function in activated B and T_FH cells restrains the GC reaction and prevents lymphomagenesis

In Special Collection:

Immunology Update Winter 2022

René Rauschmeier, Annika Reinhardt, Charlotte Gustafsson, Vassilis Glaros, Artem V. Artemov, Josefine Dunst, Reshma Taneja, Igor Adameyko, Robert Månsson, Meinrad Busslinger, Taras Kreslavsky

J Exp Med (2021) 219 (2): e20211406.

DOI: https://doi.org/10.1084/jem.20211406

Published: 17 December 2021

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Journal Articles

Takes one to B1a: Dismantling the origin of mantle cell lymphoma

Anna E. Beaudin

J Exp Med (2021) 218 (10): e20211482.

DOI: https://doi.org/10.1084/jem.20211482

Published: 16 September 2021

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Journal Articles

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

J Exp Med (2021) 218 (10): e20202280.

DOI: https://doi.org/10.1084/jem.20202280

Published: 18 August 2021

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Includes: Supplementary data

Journal Articles

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

In Special Collection:

JEM Hematologic Malignancies Collection 2021

Jennifer J. Trowbridge, Daniel T. Starczynowski

J Exp Med (2021) 218 (7): e20201544.

DOI: https://doi.org/10.1084/jem.20201544

Published: 15 June 2021

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Journal Articles

Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

In Special Collection:

Cytokines Collection 2021 , JEM Hematologic Malignancies Collection 2021 , Stem Cell Collection 2021

Kelly C. Higa, Andrew Goodspeed, James S. Chavez, Marco De Dominici, Etienne Danis, Vadym Zaberezhnyy, Jennifer L. Rabe, Daniel G. Tenen, Eric M. Pietras, James DeGregori

J Exp Med (2021) 218 (6): e20200560.

DOI: https://doi.org/10.1084/jem.20200560

Published: 29 April 2021

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Journal Articles

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

In Special Collection:

JEM Hematologic Malignancies Collection 2021

Lucille Stuani, Marie Sabatier, Estelle Saland, Guillaume Cognet, Nathalie Poupin, Claudie Bosc, Florence A. Castelli, Lara Gales, Evgenia Turtoi, Camille Montersino, Thomas Farge, Emeline Boet, Nicolas Broin, Clément Larrue, Natalia Baran, Madi Y. Cissé, Marc Conti, Sylvain Loric, Tony Kaoma, Alexis Hucteau, Aliki Zavoriti, Ambrine Sahal, Pierre-Luc Mouchel, Mathilde Gotanègre, Cédric Cassan, Laurent Fernando, Feng Wang, Mohsen Hosseini, Emeline Chu-Van, Laurent Le Cam, Martin Carroll, Mary A. Selak, Norbert Vey, Rémy Castellano, François Fenaille, Andrei Turtoi, Guillaume Cazals, Pierre Bories, Yves Gibon, Brandon Nicolay, Sébastien Ronseaux, Joseph R. Marszalek, Koichi Takahashi, Courtney D. DiNardo, Marina Konopleva, Véra Pancaldi, Yves Collette, Floriant Bellvert, Fabien Jourdan, Laetitia K. Linares, Christian Récher, Jean-Charles Portais, Jean-Emmanuel Sarry

J Exp Med (2021) 218 (5): e20200924.

DOI: https://doi.org/10.1084/jem.20200924

Published: 24 March 2021

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Includes: Supplementary data

Journal Articles

Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

In Special Collection:

JEM Hematologic Malignancies Collection 2021 , Stem Cell Collection 2021

Adeline Rosu, Najla El Hachem, Francesca Rapino, Kevin Rouault-Pierre, Joseph Jorssen, Joan Somja, Eve Ramery, Marc Thiry, Laurent Nguyen, Maarten Jacquemyn, Dirk Daelemans, Christopher M. Adams, Dominique Bonnet, Alain Chariot, Pierre Close, Fabrice Bureau, Christophe J. Desmet

J Exp Med (2021) 218 (3): e20200662.

DOI: https://doi.org/10.1084/jem.20200662

Published: 28 January 2021

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Includes: Supplementary data

Journal Articles

Stem cell origins of JMML

Sriram Sundaravel, Ulrich Steidl

J Exp Med (2021) 218 (2): e20202152.

DOI: https://doi.org/10.1084/jem.20202152

Published: 11 January 2021

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Journal Articles

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

In Special Collection:

2022 Clinical Collection on Cancer , JEM Cancer Collection 2021 , JEM Hematologic Malignancies Collection 2021 , Stem Cell Collection 2021

J Exp Med (2021) 218 (2): e20180853.

DOI: https://doi.org/10.1084/jem.20180853

Published: 08 January 2021

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Includes: Supplementary data

Journal Articles

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

In Special Collection:

Antibodies at the Forefront of Disease Treatment , JEM Hematologic Malignancies Collection 2021

Juhee Pae, Jonatan Ersching, Tiago B.R. Castro, Marta Schips, Luka Mesin, Samuel J. Allon, Jose Ordovas-Montanes, Coraline Mlynarczyk, Ari Melnick, Alejo Efeyan, Alex K. Shalek, Michael Meyer-Hermann, Gabriel D. Victora

J Exp Med (2020) 218 (4): e20201699.

DOI: https://doi.org/10.1084/jem.20201699

Published: 17 December 2020

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Includes: Supplementary data

Journal Articles

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma

In Special Collection:

JEM Hematologic Malignancies Collection 2021

Raud Razzaghi, Shreya Agarwal, Nikita Kotlov, Olga Plotnikova, Krystle Nomie, Da Wei Huang, George W. Wright, Grace A. Smith, Moyi Li, Katsuyoshi Takata, Maryam Yamadi, Chen Yao, John J. O’Shea, James D. Phelan, Stefania Pittaluga, David W. Scott, Jagan R. Muppidi

J Exp Med (2020) 218 (3): e20201173.

DOI: https://doi.org/10.1084/jem.20201173

Published: 25 November 2020

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Includes: Supplementary data

Journal Articles

A knockout combination for MPN stem cells

Megan Bywater, Steven W. Lane

J Exp Med (2020) 218 (2): e20201884.

DOI: https://doi.org/10.1084/jem.20201884

Published: 13 November 2020

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Journal Articles

Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas

In Special Collection:

2022 Clinical Collection on Cancer , JEM Hematologic Malignancies Collection 2021

Xiaofei Ye, Weicheng Ren, Dongbing Liu, Xiaobo Li, Wei Li, Xianhuo Wang, Fei-Long Meng, Leng-Siew Yeap, Yong Hou, Shida Zhu, Rafael Casellas, Huilai Zhang, Kui Wu, Qiang Pan-Hammarström

J Exp Med (2020) 218 (2): e20200573.

DOI: https://doi.org/10.1084/jem.20200573

Published: 02 November 2020

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Includes: Supplementary data

Journal Articles

JAK2^V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

In Special Collection:

JEM Hematologic Malignancies Collection 2021

Tracy Dagher, Nabih Maslah, Valérie Edmond, Bruno Cassinat, William Vainchenker, Stéphane Giraudier, Florence Pasquier, Emmanuelle Verger, Michiko Niwa-Kawakita, Valérie Lallemand-Breitenbach, Isabelle Plo, Jean-Jacques Kiladjian, Jean-Luc Villeval, Hugues de Thé

J Exp Med (2020) 218 (2): e20201268.

DOI: https://doi.org/10.1084/jem.20201268

Published: 19 October 2020

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Journal Articles

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

In Special Collection:

JEM Hematologic Malignancies Collection 2021

Begüm Alankus, Veronika Ecker, Nathalie Vahl, Martina Braun, Wilko Weichert, Stephan Macher-Göppinger, Torben Gehring, Tanja Neumayer, Thorsten Zenz, Maike Buchner, Jürgen Ruland

J Exp Med (2020) 218 (2): e20200517.

DOI: https://doi.org/10.1084/jem.20200517

Published: 14 October 2020

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Includes: Supplementary data

Journal Articles

A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy

In Special Collection:

JEM Hematologic Malignancies Collection 2021

Shannon K. Oda, Kristin G. Anderson, Pranali Ravikumar, Patrick Bonson, Nicolas M. Garcia, Cody M. Jenkins, Summer Zhuang, Andrew W. Daman, Edison Y. Chiu, Breanna M. Bates, Philip D. Greenberg

J Exp Med (2020) 217 (12): e20191166.

DOI: https://doi.org/10.1084/jem.20191166

Published: 28 August 2020

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NARROW

Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

TIRAP drives myelosuppression through an Ifnγ–Hmgb1 axis that disrupts the endothelial niche in mice

Bhlhe40 function in activated B and T_FH cells restrains the GC reaction and prevents lymphomagenesis

Takes one to B1a: Dismantling the origin of mantle cell lymphoma

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

Stem cell origins of JMML

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma

A knockout combination for MPN stem cells

Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas

JAK2^V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy

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