Page 1 | Search Results | Journal of Experimental Medicine

1-20 of 185

Sort by

Sort Order Select

Journal Articles

MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer

J Exp Med (2023) 220 (11): e20211743.

https://doi.org/10.1084/jem.20211743

Published: 29 August 2023

View article titled, MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer

Includes: Supplementary data

Journal Articles

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

J Exp Med (2023) 220 (11): e20230011.

https://doi.org/10.1084/jem.20230011

Published: 24 August 2023

View article titled, Hematopoietic-specific heterozygous loss of <em>Dnmt3a</em> exacerbates colitis-associated colon cancer

Includes: Supplementary data

Journal Articles

Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function

In Special Collection:

Tumor Microenvironment and Metastasis 2023

Jianfeng Chen, Xinyi Zhang, Xianming Tan, Pengda Liu

J Exp Med (2023) 220 (10): e20222056.

https://doi.org/10.1084/jem.20222056

Published: 29 June 2023

View article titled, Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function

Includes: Supplementary data

Journal Articles

Cancer cell plasticity and MHC-II–mediated immune tolerance promote breast cancer metastasis to lymph nodes

In Special Collection:

Tumor Microenvironment and Metastasis 2023

Pin-Ji Lei, Ethel R. Pereira, Patrik Andersson, Zohreh Amoozgar, Jan Willem Van Wijnbergen, Meghan J. O’Melia, Hengbo Zhou, Sampurna Chatterjee, William W. Ho, Jessica M. Posada, Ashwin S. Kumar, Satoru Morita, Lutz Menzel, Charlie Chung, Ilgin Ergin, Dennis Jones, Peigen Huang, Semir Beyaz, Timothy P. Padera

J Exp Med (2023) 220 (9): e20221847.

https://doi.org/10.1084/jem.20221847

Published: 21 June 2023

View article titled, Cancer cell plasticity and MHC-II–mediated immune tolerance promote breast cancer metastasis to lymph nodes

Includes: Supplementary data

Journal Articles

Obesity alters monocyte developmental trajectories to enhance metastasis

In Special Collection:

Tumor Microenvironment and Metastasis 2023

J Exp Med (2023) 220 (8): e20220509.

https://doi.org/10.1084/jem.20220509

Published: 11 May 2023

View article titled, Obesity alters monocyte developmental trajectories to enhance metastasis

Includes: Supplementary data

Journal Articles

Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages

In Special Collection:

Tumor Microenvironment and Metastasis 2023 , Metabolism Signaling

Michael A. Gonzalez, Daniel R. Lu, Maryam Yousefi, Ashley Kroll, Chen Hao Lo, Carlos G. Briseño, J. E. Vivienne Watson, Sergey Novitskiy, Vanessa Arias, Hong Zhou, Andres Plata Stapper, Min K. Tsai, Emily L. Ashkin, Christopher W. Murray, Chi-Ming Li, Monte M. Winslow, Kristin V. Tarbell

J Exp Med (2023) 220 (6): e20221472.

https://doi.org/10.1084/jem.20221472

Published: 30 March 2023

View article titled, Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages

Includes: Supplementary data

Journal Articles

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

In Special Collection:

Tumor Microenvironment and Metastasis 2023

J Exp Med (2023) 220 (6): e20212062.

https://doi.org/10.1084/jem.20212062

Published: 23 March 2023

View article titled, Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

Includes: Supplementary data

Journal Articles

IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma

In Special Collection:

JEM Cancer Collection 2023 , JEM Clinical Immunology Collection 2023

J Exp Med (2023) 220 (5): e20221952.

https://doi.org/10.1084/jem.20221952

Published: 15 March 2023

View article titled, IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma

Includes: Supplementary data

Journal Articles

Sidestepping SHP2 inhibition

Bogdan Popescu, Kevin Shannon

J Exp Med (2023) 220 (5): e20230082.

https://doi.org/10.1084/jem.20230082

Published: 03 March 2023

View article titled, Sidestepping SHP2 inhibition

Journal Articles

Pleiotrophin drives a prometastatic immune niche in breast cancer

Debolina Ganguly, Marcel O. Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T.A. Dominguez, Gilbert Z. Murimwa, Jason E. Toombs, Cheryl Lewis, Yisheng V. Fang, Fatima Valdes-Mora, David Gallego-Ortega, Anton Wellstein, Rolf A. Brekken

J Exp Med (2023) 220 (5): e20220610.

https://doi.org/10.1084/jem.20220610

Published: 24 February 2023

View article titled, Pleiotrophin drives a prometastatic immune niche in breast cancer

Includes: Supplementary data

Journal Articles

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

In Special Collection:

JEM Cancer Collection 2023

Wei Wei, Mitchell J. Geer, Xinyi Guo, Igor Dolgalev, Neville E. Sanjana, Benjamin G. Neel

J Exp Med (2023) 220 (5): e20221563.

https://doi.org/10.1084/jem.20221563

Published: 23 February 2023

View article titled, Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

Includes: Supplementary data

Journal Articles

Macrophages promote anti-androgen resistance in prostate cancer bone disease

In Special Collection:

Innate Immune Cells and Signaling 2023 , JEM Cancer Collection 2023

J Exp Med (2023) 220 (4): e20221007.

https://doi.org/10.1084/jem.20221007

Published: 07 February 2023

View article titled, Macrophages promote anti-androgen resistance in prostate cancer bone disease

Includes: Supplementary data

Journal Articles

Stopping the fat: Repurposing an antidepressant for cancer treatment

Deepika Bhullar, Cosimo Commisso

J Exp Med (2023) 220 (3): e20222097.

https://doi.org/10.1084/jem.20222097

Published: 02 February 2023

View article titled, Stopping the fat: Repurposing an antidepressant for cancer treatment

Journal Articles

MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Tumor Microenvironment and Metastasis 2023 , Metabolism Signaling

Mark R. Silvis, Dilru Silva, Riley Rohweder, Sophia Schuman, Swapna Gudipaty, Amanda Truong, Jeffrey Yap, Kajsa Affolter, Martin McMahon, Conan Kinsey

J Exp Med (2023) 220 (3): e20221524.

https://doi.org/10.1084/jem.20221524

Published: 31 January 2023

View article titled, MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition

Includes: Supplementary data

Journal Articles

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

In Special Collection:

JEM Cancer Collection 2023

Lestat R. Ali, Ana C. Garrido-Castro, Patrick J. Lenehan, Naima Bollenrucher, Courtney T. Stump, Michael Dougan, Shom Goel, Geoffrey I. Shapiro, Sara M. Tolaney, Stephanie K. Dougan

J Exp Med (2023) 220 (4): e20220729.

https://doi.org/10.1084/jem.20220729

Published: 23 January 2023

View article titled, PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Journal Articles

Tumor-derived OBP2A promotes prostate cancer castration resistance

Ji-Hak Jeong, Shangwei Zhong, Fuzhuo Li, Changhao Huang, Xueyan Chen, Qingqing Liu, Shoujiao Peng, HaJeung Park, You Mie Lee, Jasreman Dhillon, Jun-Li Luo

J Exp Med (2022) 220 (3): e20211546.

https://doi.org/10.1084/jem.20211546

Published: 22 December 2022

View article titled, Tumor-derived OBP2A promotes prostate cancer castration resistance

Includes: Supplementary data

Journal Articles

γδIL17 under control

Guillem Sanchez Sanchez, David Vermijlen

J Exp Med (2022) 220 (2): e20221921.

https://doi.org/10.1084/jem.20221921

Published: 15 December 2022

View article titled, γδIL17 under control

Journal Articles

Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

Akiko Nakayama, Kenneth Anthony Roquid, András Iring, Boris Strilic, Stefan Günther, Min Chen, Lee S. Weinstein, Stefan Offermanns

J Exp Med (2022) 220 (1): e20211628.

https://doi.org/10.1084/jem.20211628

Published: 14 November 2022

View article titled, Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

Includes: Supplementary data

Journal Articles

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

J Exp Med (2022) 220 (1): e20202595.

https://doi.org/10.1084/jem.20202595

Published: 21 October 2022

View article titled, Primary tumor–derived systemic nANGPTL4 inhibits metastasis

Includes: Supplementary data

Journal Articles

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

In Special Collection:

Immunology Update Winter 2023 , JEM Cancer Collection 2023

Wenting Du, Rosa E. Menjivar, Katelyn L. Donahue, Padma Kadiyala, Ashley Velez-Delgado, Kristee L. Brown, Hannah R. Watkoske, Xi He, Eileen S. Carpenter, Christina V. Angeles, Yaqing Zhang, Marina Pasca di Magliano

J Exp Med (2022) 220 (1): e20220503.

https://doi.org/10.1084/jem.20220503

Published: 14 October 2022

View article titled, WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

Includes: Supplementary data

NARROW

MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function

Cancer cell plasticity and MHC-II–mediated immune tolerance promote breast cancer metastasis to lymph nodes

Obesity alters monocyte developmental trajectories to enhance metastasis

Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma

Sidestepping SHP2 inhibition

Pleiotrophin drives a prometastatic immune niche in breast cancer

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

Macrophages promote anti-androgen resistance in prostate cancer bone disease

Stopping the fat: Repurposing an antidepressant for cancer treatment

MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Tumor-derived OBP2A promotes prostate cancer castration resistance

γδIL17 under control

Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

Email alerts

Email alerts

This Feature Is Available To Subscribers Only