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Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

J Exp Med (2023) 220 (6): e20212062.

DOI: https://doi.org/10.1084/jem.20212062

Published: 23 March 2023

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Includes: Supplementary data

Journal Articles

IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma

J Exp Med (2023) 220 (5): e20221952.

DOI: https://doi.org/10.1084/jem.20221952

Published: 15 March 2023

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Includes: Supplementary data

Journal Articles

IFNγ score–based neoadjuvant immunotherapy for stage III melanoma

Keitaro Fukuda

J Exp Med (2023) 220 (5): e20230160.

DOI: https://doi.org/10.1084/jem.20230160

Published: 15 March 2023

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Journal Articles

Pleiotrophin drives a prometastatic immune niche in breast cancer

Debolina Ganguly, Marcel O. Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T.A. Dominguez, Gilbert Z. Murimwa, Jason E. Toombs, Cheryl Lewis, Yisheng V. Fang, Fatima Valdes-Mora, David Gallego-Ortega, Anton Wellstein, Rolf A. Brekken

J Exp Med (2023) 220 (5): e20220610.

DOI: https://doi.org/10.1084/jem.20220610

Published: 24 February 2023

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Includes: Supplementary data

Journal Articles

Macrophages and bone metastasis

Diletta Di Mitri, Fabio Conforti, Alberto Mantovani

J Exp Med (2023) 220 (4): e20222188.

DOI: https://doi.org/10.1084/jem.20222188

Published: 24 February 2023

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Journal Articles

Macrophages promote anti-androgen resistance in prostate cancer bone disease

J Exp Med (2023) 220 (4): e20221007.

DOI: https://doi.org/10.1084/jem.20221007

Published: 07 February 2023

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Includes: Supplementary data

Journal Articles

STAT3 regulates CD8⁺ T cell differentiation and functions in cancer and acute infection

Qinli Sun, Xiaohong Zhao, Ruifeng Li, Dingfeng Liu, Birui Pan, Bowen Xie, Xinxin Chi, Dongli Cai, Peng Wei, Wei Xu, Kun Wei, Zixuan Zhao, Yujie Fu, Ling Ni, Chen Dong

J Exp Med (2023) 220 (4): e20220686.

DOI: https://doi.org/10.1084/jem.20220686

Published: 23 January 2023

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Includes: Supplementary data

Journal Articles

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Lestat R. Ali, Ana C. Garrido-Castro, Patrick J. Lenehan, Naima Bollenrucher, Courtney T. Stump, Michael Dougan, Shom Goel, Geoffrey I. Shapiro, Sara M. Tolaney, Stephanie K. Dougan

J Exp Med (2023) 220 (4): e20220729.

DOI: https://doi.org/10.1084/jem.20220729

Published: 23 January 2023

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Journal Articles

Microbiome influencers of checkpoint blockade–associated toxicity

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM)

Yinghong Wang, Robert R. Jenq, Jennifer A. Wargo, Stephanie S. Watowich

J Exp Med (2023) 220 (3): e20220948.

DOI: https://doi.org/10.1084/jem.20220948

Published: 09 January 2023

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Journal Articles

γδIL17 under control

Guillem Sanchez Sanchez, David Vermijlen

J Exp Med (2022) 220 (2): e20221921.

DOI: https://doi.org/10.1084/jem.20221921

Published: 15 December 2022

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Journal Articles

PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

In Special Collection:

Immunology Update Winter 2023

Sarah C. Edwards, Ann Hedley, Wilma H.M. Hoevenaar, Robert Wiesheu, Teresa Glauner, Anna Kilbey, Robin Shaw, Katerina Boufea, Nizar Batada, Shinya Hatano, Yasunobu Yoshikai, Karen Blyth, Crispin Miller, Kristina Kirschner, Seth B. Coffelt

J Exp Med (2022) 220 (2): e20211431.

DOI: https://doi.org/10.1084/jem.20211431

Published: 07 December 2022

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Includes: Supplementary data

Journal Articles

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Immunology Update Winter 2023

J Exp Med (2022) 220 (2): e20221333.

DOI: https://doi.org/10.1084/jem.20221333

Published: 11 November 2022

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Includes: Supplementary data

Journal Articles

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8⁺ T cells

Tarun Tyagi, Kanika Jain, Timur O. Yarovinsky, Michael Chiorazzi, Jing Du, Cecilia Castro, Jules Griffin, Asawari Korde, Kathleen A. Martin, Shervin S. Takyar, Richard A. Flavell, Abhijit A. Patel, John Hwa

J Exp Med (2022) 220 (1): e20212218.

DOI: https://doi.org/10.1084/jem.20212218

Published: 28 October 2022

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Includes: Supplementary data

Journal Articles

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

In Special Collection:

Immunology Update Winter 2023

Wenting Du, Rosa E. Menjivar, Katelyn L. Donahue, Padma Kadiyala, Ashley Velez-Delgado, Kristee L. Brown, Hannah R. Watkoske, Xi He, Eileen S. Carpenter, Christina V. Angeles, Yaqing Zhang, Marina Pasca di Magliano

J Exp Med (2022) 220 (1): e20220503.

DOI: https://doi.org/10.1084/jem.20220503

Published: 14 October 2022

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Includes: Supplementary data

Journal Articles

Eating away T cell responses in lung cancer

Roberto Ferrara, Luca Roz

J Exp Med (2022) 219 (12): e20221449.

DOI: https://doi.org/10.1084/jem.20221449

Published: 10 October 2022

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Journal Articles

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

J Exp Med (2022) 219 (12): e20211476.

DOI: https://doi.org/10.1084/jem.20211476

Published: 30 September 2022

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Includes: Supplementary data

Journal Articles

An engineered concealed IL-15-R elicits tumor-specific CD8⁺T cell responses through PD-1-cis delivery

In Special Collection:

JEM Cancer Immunotherapy 2022

Jiao Shen, Zhuangzhi Zou, Jingya Guo, Yueqi Cai, Diyuan Xue, Yong Liang, Wenyan Wang, Hua Peng, Yang-Xin Fu

J Exp Med (2022) 219 (12): e20220745.

DOI: https://doi.org/10.1084/jem.20220745

Published: 27 September 2022

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Includes: Supplementary data

Journal Articles

Bringing natural killer cells to the clinic

Laura Chiossone, Eric Vivier

J Exp Med (2022) 219 (10): e20220830.

DOI: https://doi.org/10.1084/jem.20220830

Published: 06 September 2022

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Journal Articles

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

In Special Collection:

Hematology 2022

Yu Rebecca Miao, Kaushik Thakkar, Can Cenik, Dadi Jiang, Kazue Mizuno, Chenjun Jia, Caiyun Grace Li, Hongjuan Zhao, Anh Diep, Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-sze Leung, Albert C. Koong, Amato J. Giaccia

J Exp Med (2022) 219 (9): e20220214.

DOI: https://doi.org/10.1084/jem.20220214

Published: 26 July 2022

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Includes: Supplementary data

Journal Articles

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

In Special Collection:

JEM Cancer Immunotherapy 2022

Alessandro Camponeschi, Kathrin Kläsener, Timothy Sundell, Christina Lundqvist, Paul T. Manna, Negar Ayoubzadeh, Martina Sundqvist, Katrin Thorarinsdottir, Mariele Gatto, Marcella Visentini, Karin Önnheim, Alaitz Aranburu, Huamei Forsman, Olov Ekwall, Linda Fogelstrand, Inger Gjertsson, Michael Reth, Inga-Lill Mårtensson

J Exp Med (2022) 219 (9): e20220201.

DOI: https://doi.org/10.1084/jem.20220201

Published: 12 July 2022

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Includes: Supplementary data

NARROW

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma

IFNγ score–based neoadjuvant immunotherapy for stage III melanoma

Pleiotrophin drives a prometastatic immune niche in breast cancer

Macrophages and bone metastasis

Macrophages promote anti-androgen resistance in prostate cancer bone disease

STAT3 regulates CD8⁺ T cell differentiation and functions in cancer and acute infection

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Microbiome influencers of checkpoint blockade–associated toxicity

γδIL17 under control

PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8⁺ T cells

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

Eating away T cell responses in lung cancer

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

An engineered concealed IL-15-R elicits tumor-specific CD8⁺T cell responses through PD-1-cis delivery

Bringing natural killer cells to the clinic

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

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