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Regulatory T cells suppress CD4⁺ effector T cell activation by controlling protein synthesis

Lomon So, Kazushige Obata-Ninomiya, Alex Hu, Virginia S. Muir, Ayako Takamori, Jing Song, Jane H. Buckner, Ram Savan, Steven F. Ziegler

J Exp Med (2023) 220 (3): e20221676.

DOI: https://doi.org/10.1084/jem.20221676

Published: 04 January 2023

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Includes: Supplementary data

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How decreasing T cell signaling unexpectedly results in autoimmunity

Jaeu Yi, Chyi-Song Hsieh

J Exp Med (2022) 220 (2): e20221886.

DOI: https://doi.org/10.1084/jem.20221886

Published: 15 December 2022

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Journal Articles

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

J Exp Med (2022) 220 (2): e20220386.

DOI: https://doi.org/10.1084/jem.20220386

Published: 01 December 2022

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Includes: Supplementary data

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Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

J Exp Med (2022) 220 (1): e20220829.

DOI: https://doi.org/10.1084/jem.20220829

Published: 08 November 2022

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Includes: Supplementary data

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The X factor in neurodegeneration

Rhonda Voskuhl, Yuichiro Itoh

J Exp Med (2022) 219 (12): e20211488.

DOI: https://doi.org/10.1084/jem.20211488

Published: 04 November 2022

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Journal Articles

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

In Special Collection:

Immunology Update Winter 2023 , Tolerance and Autoimmunity

Vidyanath Chaudhary, Marie Dominique Ah Kioon, Sung-Min Hwang, Bikash Mishra, Kimberly Lakin, Kyriakos A. Kirou, Jeffrey Zhang-Sun, R. Luke Wiseman, Robert F. Spiera, Mary K. Crow, Jessica K. Gordon, Juan R. Cubillos-Ruiz, Franck J. Barrat

J Exp Med (2022) 219 (11): e20221085.

DOI: https://doi.org/10.1084/jem.20221085

Published: 02 September 2022

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Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice

In Special Collection:

Lymphatic Vessels in Health and Disease 2022

Xiaopeng Wu, Achia Khatun, Moujtaba Y. Kasmani, Yao Chen, Shikan Zheng, Samantha Atkinson, Christine Nguyen, Robert Burns, Elizabeth J. Taparowsky, Nita H. Salzman, Timothy W. Hand, Weiguo Cui

J Exp Med (2022) 219 (11): e20211861.

DOI: https://doi.org/10.1084/jem.20211861

Published: 01 September 2022

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Journal Articles

Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

In Special Collection:

Tolerance and Autoimmunity

J Exp Med (2022) 219 (11): e20220650.

DOI: https://doi.org/10.1084/jem.20220650

Published: 01 September 2022

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Includes: Supplementary data

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Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

In Special Collection:

Tolerance and Autoimmunity

J Exp Med (2022) 219 (10): e20220759.

DOI: https://doi.org/10.1084/jem.20220759

Published: 23 August 2022

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Includes: Supplementary data

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Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response

In Special Collection:

Cytokines Collection 2022 , Tolerance and Autoimmunity

J Exp Med (2022) 219 (9): e20212126.

DOI: https://doi.org/10.1084/jem.20212126

Published: 14 July 2022

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Includes: Supplementary data

Journal Articles

IL-24 intrinsically regulates Th17 cell pathogenicity in mice

In Special Collection:

Cytokines Collection 2022

Christopher Sie, Ravi Kant, Christian Peter, Andreas Muschaweckh, Monika Pfaller, Lucy Nirschl, Helena Domínguez Moreno, Tereza Chadimová, Gildas Lepennetier, Tanja Kuhlmann, Rupert Öllinger, Thomas Engleitner, Roland Rad, Thomas Korn

J Exp Med (2022) 219 (8): e20212443.

DOI: https://doi.org/10.1084/jem.20212443

Published: 12 July 2022

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Includes: Supplementary data

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Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs

In Special Collection:

Lymphatic Vessels in Health and Disease 2022

Ho-Sup Lee, Hao Sun, Frédéric Lagarrigue, Sarah Hyun Ji Kim, Jay W. Fox, Nicholas E. Sherman, Alexandre R. Gingras, Mark H. Ginsberg

J Exp Med (2022) 219 (8): e20211637.

DOI: https://doi.org/10.1084/jem.20211637

Published: 29 June 2022

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CXCR4⁺ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow

Shlomo Elias, Rahul Sharma, Michael Schizas, Izabella Valdez, Sham Rampersaud, Sun-Mi Park, Paula Gonzalez-Figueroa, Quan-Zhen Li, Beatrice Hoyos, Alexander Y. Rudensky

J Exp Med (2022) 219 (7): e20220047.

DOI: https://doi.org/10.1084/jem.20220047

Published: 07 June 2022

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Journal Articles

Fueling the fire in the gut

Chia-Hao Lin, Li-Fan Lu

J Exp Med (2022) 219 (7): e20220723.

DOI: https://doi.org/10.1084/jem.20220723

Published: 27 May 2022

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Journal Articles

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

In Special Collection:

JEM Cancer Immunotherapy 2022 , JEM Clinical Immunology Collection 2022 , Mechanisms and Models of Cancer 2022 Update

J Exp Med (2022) 219 (6): e20212169.

DOI: https://doi.org/10.1084/jem.20212169

Published: 23 May 2022

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Includes: Supplementary data

Journal Articles

SARS-CoV-2 infection relaxes peripheral B cell tolerance

In Special Collection:

JEM Clinical Immunology Collection 2022

Moriah J. Castleman, Megan M. Stumpf, Nicholas R. Therrien, Mia J. Smith, Kelsey E. Lesteberg, Brent E. Palmer, James P. Maloney, William J. Janssen, Kara J. Mould, J. David Beckham, Roberta Pelanda, Raul M. Torres

J Exp Med (2022) 219 (6): e20212553.

DOI: https://doi.org/10.1084/jem.20212553

Published: 14 April 2022

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Includes: Supplementary data

Journal Articles

Human autoantibodies underlying infectious diseases

In Special Collection:

Innate Immunity: From Basic Biology to Human Disease

Anne Puel, Paul Bastard, Jacinta Bustamante, Jean-Laurent Casanova

J Exp Med (2022) 219 (4): e20211387.

DOI: https://doi.org/10.1084/jem.20211387

Published: 23 March 2022

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Journal Articles

Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25

In Special Collection:

Lymphatic Vessels in Health and Disease 2022

Dongeon Kim, Mingyo Kim, Tae Woo Kim, Yong-ho Choe, Hae Sook Noh, Hyun Min Jeon, HyunSeok Kim, Youngeun Lee, Gayeong Hur, Kyung-Mi Lee, Kihyuk Shin, Sang-il Lee, Seung-Hyo Lee

J Exp Med (2022) 219 (5): e20200795.

DOI: https://doi.org/10.1084/jem.20200795

Published: 22 March 2022

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Includes: Supplementary data

Journal Articles

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

In Special Collection:

Innate Immunity: From Basic Biology to Human Disease , Neuroscience Collection 2022

J Exp Med (2022) 219 (4): e20211121.

DOI: https://doi.org/10.1084/jem.20211121

Published: 09 March 2022

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Includes: Supplementary data

Journal Articles

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis

Tarin M. Bigley, Liping Yang, Liang-I Kang, Jose B. Saenz, Francisco Victorino, Wayne M. Yokoyama

J Exp Med (2022) 219 (3): e20211403.

DOI: https://doi.org/10.1084/jem.20211403

Published: 28 February 2022

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2 3 4 5

NARROW

Regulatory T cells suppress CD4⁺ effector T cell activation by controlling protein synthesis

How decreasing T cell signaling unexpectedly results in autoimmunity

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

The X factor in neurodegeneration

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice

Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response

IL-24 intrinsically regulates Th17 cell pathogenicity in mice

Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs

CXCR4⁺ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow

Fueling the fire in the gut

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

SARS-CoV-2 infection relaxes peripheral B cell tolerance

Human autoantibodies underlying infectious diseases

Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis

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