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STING trafficking as a new dimension of immune signaling

Devon Jeltema, Kennady Abbott, Nan Yan

J Exp Med (2023) 220 (3): e20220990.

DOI: https://doi.org/10.1084/jem.20220990

Published: 27 January 2023

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Journal Articles

Gut microbiota biofilms: From regulatory mechanisms to therapeutic targets

Andre G. Buret, Thibault Allain

J Exp Med (2023) 220 (3): e20221743.

DOI: https://doi.org/10.1084/jem.20221743

Published: 23 January 2023

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Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6⁺ ILC3s

Yuling Li, Jing Ge, Xiaohong Zhao, Miao Xu, Mengting Gou, Bowen Xie, Jinling Huang, Qinli Sun, Lin Sun, Xue Bai, Sangnee Tan, Xiaohu Wang, Chen Dong

J Exp Med (2023) 220 (4): e20220440.

DOI: https://doi.org/10.1084/jem.20220440

Published: 18 January 2023

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Includes: Supplementary data

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Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation

Kang I. Ko, Brett P. DerGarabedian, Zhaoxu Chen, Rahul Debnath, Annette Ko, Brittany N. Link, Jonathan M. Korostoff, Dana T. Graves

J Exp Med (2022) 220 (3): e20221350.

DOI: https://doi.org/10.1084/jem.20221350

Published: 30 December 2022

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Includes: Supplementary data

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Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies

Achraf Shamseddine, Suchit H. Patel, Valery Chavez, Zachary R. Moore, Mutayyaba Adnan, Melody Di Bona, Jun Li, Chau T. Dang, Lakshmi V. Ramanathan, Kevin C. Oeffinger, Jennifer E. Liu, Richard M. Steingart, Alessandra Piersigilli, Nicholas D. Socci, Angel T. Chan, Anthony F. Yu, Samuel F. Bakhoum, Adam M. Schmitt

J Exp Med (2022) 220 (3): e20220809.

DOI: https://doi.org/10.1084/jem.20220809

Published: 19 December 2022

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Includes: Supplementary data

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PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

In Special Collection:

Immunology Update Winter 2023

Sarah C. Edwards, Ann Hedley, Wilma H.M. Hoevenaar, Robert Wiesheu, Teresa Glauner, Anna Kilbey, Robin Shaw, Katerina Boufea, Nizar Batada, Shinya Hatano, Yasunobu Yoshikai, Karen Blyth, Crispin Miller, Kristina Kirschner, Seth B. Coffelt

J Exp Med (2022) 220 (2): e20211431.

DOI: https://doi.org/10.1084/jem.20211431

Published: 07 December 2022

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Includes: Supplementary data

Journal Articles

NLRP1 activation by UVB: Shedding light on an enigmatic inflammasome

Andrew Sandstrom

J Exp Med (2022) 220 (1): e20221720.

DOI: https://doi.org/10.1084/jem.20221720

Published: 14 November 2022

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Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Immunology Update Winter 2023

J Exp Med (2022) 220 (2): e20221333.

DOI: https://doi.org/10.1084/jem.20221333

Published: 11 November 2022

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Includes: Supplementary data

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Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

J Exp Med (2022) 220 (1): e20220829.

DOI: https://doi.org/10.1084/jem.20220829

Published: 08 November 2022

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Includes: Supplementary data

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P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

J Exp Med (2022) 220 (1): e20220837.

DOI: https://doi.org/10.1084/jem.20220837

Published: 31 October 2022

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Includes: Supplementary data

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Metabolic features of innate lymphoid cells

Huiyang Yu, Nicolas Jacquelot, Gabrielle T. Belz

J Exp Med (2022) 219 (11): e20221140.

DOI: https://doi.org/10.1084/jem.20221140

Published: 27 October 2022

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Journal Articles

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

J Exp Med (2022) 219 (12): e20211476.

DOI: https://doi.org/10.1084/jem.20211476

Published: 30 September 2022

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Includes: Supplementary data

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CARD8 makes coxsackievirus more “heartbreaking”

Qiankun Wang, Liang Shan

J Exp Med (2022) 219 (10): e20221240.

DOI: https://doi.org/10.1084/jem.20221240

Published: 21 September 2022

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Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

In Special Collection:

2022: The Year in Experimental Medicine

Rhea Nadkarni, Wern Cui Chu, Cheryl Q.E. Lee, Yasir Mohamud, Lynn Yap, Gee Ann Toh, Sheryl Beh, Radiance Lim, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Kim Robinson, Karl Tryggvason, Honglin Luo, Franklin Zhong, Lena Ho

J Exp Med (2022) 219 (10): e20212117.

DOI: https://doi.org/10.1084/jem.20212117

Published: 21 September 2022

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Includes: Supplementary data

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Sleep exerts lasting effects on hematopoietic stem cell function and diversity

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Hematology 2022 , 2022: The Year in Experimental Medicine

J Exp Med (2022) 219 (11): e20220081.

DOI: https://doi.org/10.1084/jem.20220081

Published: 21 September 2022

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Includes: Supplementary data

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Impaired immune response drives age-dependent severity of COVID-19

J Exp Med (2022) 219 (12): e20220621.

DOI: https://doi.org/10.1084/jem.20220621

Published: 21 September 2022

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Includes: Supplementary data

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The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium

Monica T. Jimenez, Megan L. Clark, Jasmine M. Wright, Michaël F. Michieletto, Suying Liu, Isabel Erickson, Lenka Dohnalova, Giulia T. Uhr, John Tello-Cajiao, Leonel Joannas, Adam Williams, Nicola Gagliani, Meenakshi Bewtra, Vesselin T. Tomov, Christoph A. Thaiss, Jorge Henao-Mejia

J Exp Med (2022) 219 (12): e20212278.

DOI: https://doi.org/10.1084/jem.20212278

Published: 08 September 2022

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Includes: Supplementary data

Journal Articles

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Eduardo P. Amaral, Taylor W. Foreman, Sivaranjani Namasivayam, Kerry L. Hilligan, Keith D. Kauffman, Caio Cesar Barbosa Bomfim, Diego L. Costa, Beatriz Barreto-Duarte, Clarissa Gurgel-Rocha, Monique Freire Santana, Marcelo Cordeiro-Santos, Elsa Du Bruyn, Catherine Riou, Kate Aberman, Robert John Wilkinson, Daniel L. Barber, Katrin D. Mayer-Barber, Bruno B. Andrade, Alan Sher

J Exp Med (2022) 219 (11): e20220504.

DOI: https://doi.org/10.1084/jem.20220504

Published: 07 September 2022

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Includes: Supplementary data

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Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression

Avishai Shemesh, Yapeng Su, Daniel R. Calabrese, Daniel Chen, Janice Arakawa-Hoyt, Kole T. Roybal, James R. Heath, John R. Greenland, Lewis L. Lanier

J Exp Med (2022) 219 (11): e20220551.

DOI: https://doi.org/10.1084/jem.20220551

Published: 06 September 2022

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Journal Articles

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

In Special Collection:

Immunology Update Winter 2023 , Tolerance and Autoimmunity

Vidyanath Chaudhary, Marie Dominique Ah Kioon, Sung-Min Hwang, Bikash Mishra, Kimberly Lakin, Kyriakos A. Kirou, Jeffrey Zhang-Sun, R. Luke Wiseman, Robert F. Spiera, Mary K. Crow, Jessica K. Gordon, Juan R. Cubillos-Ruiz, Franck J. Barrat

J Exp Med (2022) 219 (11): e20221085.

DOI: https://doi.org/10.1084/jem.20221085

Published: 02 September 2022

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Includes: Supplementary data

2 3 4 5

NARROW

STING trafficking as a new dimension of immune signaling

Gut microbiota biofilms: From regulatory mechanisms to therapeutic targets

Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6⁺ ILC3s

Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation

Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies

PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

NLRP1 activation by UVB: Shedding light on an enigmatic inflammasome

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Metabolic features of innate lymphoid cells

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

CARD8 makes coxsackievirus more “heartbreaking”

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

Sleep exerts lasting effects on hematopoietic stem cell function and diversity

Impaired immune response drives age-dependent severity of COVID-19

The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

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