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Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses

In Special Collection:

Immunology Update Winter 2023

Suzanne H. Hodge, Maria Z. Krauss, Irem Kaymak, James I. King, Andrew J.M. Howden, Gordana Panic, Richard K. Grencis, Jonathan R. Swann, Linda V. Sinclair, Matthew R. Hepworth

J Exp Med (2022) 220 (3): e20221073.

DOI: https://doi.org/10.1084/jem.20221073

Published: 26 December 2022

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Journal Articles

Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition

Qiaoyun Chu, Jing An, Ping Liu, Yihan Song, Xuewei Zhai, Ronghui Yang, Jing Niu, Chuanzhen Yang, Binghui Li

J Exp Med (2022) 220 (3): e20221316.

DOI: https://doi.org/10.1084/jem.20221316

Published: 15 December 2022

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Includes: Supplementary data

Journal Articles

Metabolic features of innate lymphoid cells

Huiyang Yu, Nicolas Jacquelot, Gabrielle T. Belz

J Exp Med (2022) 219 (11): e20221140.

DOI: https://doi.org/10.1084/jem.20221140

Published: 27 October 2022

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Journal Articles

Eating away T cell responses in lung cancer

Roberto Ferrara, Luca Roz

J Exp Med (2022) 219 (12): e20221449.

DOI: https://doi.org/10.1084/jem.20221449

Published: 10 October 2022

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Journal Articles

Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice

Catalina Cosovanu, Philipp Resch, Stefan Jordan, Andrea Lehmann, Markus Ralser, Vadim Farztdinov, Joachim Spranger, Michael Mülleder, Sebastian Brachs, Christian Neumann

J Exp Med (2022) 219 (12): e20220233.

DOI: https://doi.org/10.1084/jem.20220233

Published: 19 September 2022

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Includes: Supplementary data

Journal Articles

Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47

Chong Yang, Rui Yokomori, Lee Hui Chua, Shi Hao Tan, Darren Qiancheng Tan, Kenichi Miharada, Takaomi Sanda, Toshio Suda

J Exp Med (2022) 219 (12): e20220685.

DOI: https://doi.org/10.1084/jem.20220685

Published: 16 September 2022

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Journal Articles

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Eduardo P. Amaral, Taylor W. Foreman, Sivaranjani Namasivayam, Kerry L. Hilligan, Keith D. Kauffman, Caio Cesar Barbosa Bomfim, Diego L. Costa, Beatriz Barreto-Duarte, Clarissa Gurgel-Rocha, Monique Freire Santana, Marcelo Cordeiro-Santos, Elsa Du Bruyn, Catherine Riou, Kate Aberman, Robert John Wilkinson, Daniel L. Barber, Katrin D. Mayer-Barber, Bruno B. Andrade, Alan Sher

J Exp Med (2022) 219 (11): e20220504.

DOI: https://doi.org/10.1084/jem.20220504

Published: 07 September 2022

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Includes: Supplementary data

Journal Articles

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

In Special Collection:

Immunology Update Winter 2023 , Tolerance and Autoimmunity

Vidyanath Chaudhary, Marie Dominique Ah Kioon, Sung-Min Hwang, Bikash Mishra, Kimberly Lakin, Kyriakos A. Kirou, Jeffrey Zhang-Sun, R. Luke Wiseman, Robert F. Spiera, Mary K. Crow, Jessica K. Gordon, Juan R. Cubillos-Ruiz, Franck J. Barrat

J Exp Med (2022) 219 (11): e20221085.

DOI: https://doi.org/10.1084/jem.20221085

Published: 02 September 2022

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Includes: Supplementary data

Journal Articles

Delineating a serotonin 1B receptor circuit for appetite suppression in mice

In Special Collection:

Neuroscience Collection 2022

Li Li, Steven C. Wyler, Luis A. León-Mercado, Baijie Xu, Youjin Oh, Swati, Xiameng Chen, Rong Wan, Amanda G. Arnold, Lin Jia, Guanlin Wang, Katherine Nautiyal, René Hen, Jong-Woo Sohn, Chen Liu

J Exp Med (2022) 219 (8): e20212307.

DOI: https://doi.org/10.1084/jem.20212307

Published: 07 July 2022

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Journal Articles

CXCR4⁺ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow

Shlomo Elias, Rahul Sharma, Michael Schizas, Izabella Valdez, Sham Rampersaud, Sun-Mi Park, Paula Gonzalez-Figueroa, Quan-Zhen Li, Beatrice Hoyos, Alexander Y. Rudensky

J Exp Med (2022) 219 (7): e20220047.

DOI: https://doi.org/10.1084/jem.20220047

Published: 07 June 2022

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Includes: Supplementary data

Journal Articles

Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12⁺ macrophages

In Special Collection:

JEM Mucosal Immunology 2022 , 2022: The Year in Experimental Medicine

Zhipeng Li, Manoj Gurung, Richard R. Rodrigues, Jyothi Padiadpu, Nolan K. Newman, Nathan P. Manes, Jacob W. Pederson, Renee L. Greer, Stephany Vasquez-Perez, Hyekyoung You, Kaito A. Hioki, Zoe Moulton, Anna Fel, Dominic De Nardo, Amiran K. Dzutsev, Aleksandra Nita-Lazar, Giorgio Trinchieri, Natalia Shulzhenko, Andrey Morgun

J Exp Med (2022) 219 (7): e20220017.

DOI: https://doi.org/10.1084/jem.20220017

Published: 03 June 2022

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Includes: Supplementary data

Journal Articles

Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming

Ruo-Ran Wang, Xinyuan Qiu, Ran Pan, Hongxing Fu, Ziyin Zhang, Qintao Wang, Haide Chen, Qing-Qian Wu, Xiaowen Pan, Yanping Zhou, Pengfei Shan, Shusen Wang, Guoji Guo, Min Zheng, Lingyun Zhu, Zhuo-Xian Meng

J Exp Med (2022) 219 (7): e20211779.

DOI: https://doi.org/10.1084/jem.20211779

Published: 02 June 2022

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Includes: Supplementary data

Journal Articles

Fueling the fire in the gut

Chia-Hao Lin, Li-Fan Lu

J Exp Med (2022) 219 (7): e20220723.

DOI: https://doi.org/10.1084/jem.20220723

Published: 27 May 2022

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Journal Articles

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

Antonia Katsouda, Dimitrios Valakos, Vasilios S. Dionellis, Sofia-Iris Bibli, Ioannis Akoumianakis, Sevasti Karaliota, Karim Zuhra, Ingrid Fleming, Noriyuki Nagahara, Sophia Havaki, Vassilis G. Gorgoulis, Dimitris Thanos, Charalambos Antoniades, Csaba Szabo, Andreas Papapetropoulos

J Exp Med (2022) 219 (7): e20211894.

DOI: https://doi.org/10.1084/jem.20211894

Published: 26 May 2022

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Includes: Supplementary data

Journal Articles

Role of adipose tissue macrophages in obesity-related disorders

Svetoslav Chakarov, Camille Blériot, Florent Ginhoux

J Exp Med (2022) 219 (7): e20211948.

DOI: https://doi.org/10.1084/jem.20211948

Published: 11 May 2022

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Journal Articles

CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate

Yiliang Chen, Jue Zhang, Weiguo Cui, Roy L. Silverstein

J Exp Med (2022) 219 (6): e20211314.

DOI: https://doi.org/10.1084/jem.20211314

Published: 19 April 2022

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Journal Articles

Calcium burns beige

Jakub Bunk, Lawrence Kazak

J Exp Med (2022) 219 (5): e20220382.

DOI: https://doi.org/10.1084/jem.20220382

Published: 12 April 2022

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Journal Articles

FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics

Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Zhenji Gan

J Exp Med (2022) 219 (5): e20212491.

DOI: https://doi.org/10.1084/jem.20212491

Published: 12 April 2022

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Includes: Supplementary data

Journal Articles

Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin

Mattia Quattrocelli, Michelle Wintzinger, Karen Miz, Manoj Panta, Ashok D. Prabakaran, Grant D. Barish, Navdeep S. Chandel, Elizabeth M. McNally

J Exp Med (2022) 219 (5): e20211906.

DOI: https://doi.org/10.1084/jem.20211906

Published: 01 April 2022

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Includes: Supplementary data

Journal Articles

Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors

In Special Collection:

Mechanisms and Models of Cancer 2022 Update

Honglin Jiang, Ryan K. Muir, Ryan L. Gonciarz, Adam B. Olshen, Iwei Yeh, Byron C. Hann, Ning Zhao, Yung-hua Wang, Spencer C. Behr, James E. Korkola, Michael J. Evans, Eric A. Collisson, Adam R. Renslo

J Exp Med (2022) 219 (4): e20210739.

DOI: https://doi.org/10.1084/jem.20210739

Published: 09 March 2022

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Includes: Supplementary data

2 3 4 5

NARROW

Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses

Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition

Metabolic features of innate lymphoid cells

Eating away T cell responses in lung cancer

Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice

Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

Delineating a serotonin 1B receptor circuit for appetite suppression in mice

CXCR4⁺ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow

Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12⁺ macrophages

Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming

Fueling the fire in the gut

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

Role of adipose tissue macrophages in obesity-related disorders

CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate

Calcium burns beige

FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics

Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin

Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors

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