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Engineering mighty microglia

Adeline E. Walsh, John R. Lukens

J Exp Med (2023) 220 (3): e20222070.

DOI: https://doi.org/10.1084/jem.20222070

Published: 17 January 2023

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Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

J Exp Med (2022) 220 (3): e20220857.

DOI: https://doi.org/10.1084/jem.20220857

Published: 30 December 2022

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Includes: Supplementary data

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Targeting neuroinflammation in neuropathic pain and opioid use

Daniela Salvemini, Timothy M. Doyle

J Exp Med (2022) 220 (2): e20221244.

DOI: https://doi.org/10.1084/jem.20221244

Published: 23 December 2022

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Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice

Rafael T. Han, Ilia D. Vainchtein, Johannes C.M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Eunji Ahn, Dong Kyu Kim, Jerika J. Barron, Hiromi Nakao-Inoue, Ari B. Molofsky, Christopher K. Glass, Jeanne T. Paz, Anna V. Molofsky

J Exp Med (2022) 220 (2): e20220605.

DOI: https://doi.org/10.1084/jem.20220605

Published: 15 December 2022

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Includes: Supplementary data

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Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma

Trishna Shah, Sue E. Leurgans, Rashi I. Mehta, Jingyun Yang, Chad A. Galloway, Karen L. de Mesy Bentley, Julie A. Schneider, Rupal I. Mehta

J Exp Med (2022) 220 (2): e20220618.

DOI: https://doi.org/10.1084/jem.20220618

Published: 05 December 2022

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Includes: Supplementary data

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The X factor in neurodegeneration

Rhonda Voskuhl, Yuichiro Itoh

J Exp Med (2022) 219 (12): e20211488.

DOI: https://doi.org/10.1084/jem.20211488

Published: 04 November 2022

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Journal Articles

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

Nimansha Jain, Caroline A. Lewis, Jason D. Ulrich, David M. Holtzman

J Exp Med (2022) 220 (1): e20220654.

DOI: https://doi.org/10.1084/jem.20220654

Published: 11 October 2022

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Includes: Supplementary data

Journal Articles

Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

In Special Collection:

Tolerance and Autoimmunity

J Exp Med (2022) 219 (11): e20220650.

DOI: https://doi.org/10.1084/jem.20220650

Published: 01 September 2022

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Includes: Supplementary data

Journal Articles

Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis

In Special Collection:

Immunology Update Winter 2023 , Neuroscience Collection 2022 , Tolerance and Autoimmunity

Shen-zhao Lu, Yue Wu, Yong-shun Guo, Pei-zhou Liang, Shu Yin, Yan-qing Yin, Xiu-li Zhang, Yan-Fang Liu, Hong-yan Wang, Yi-chuan Xiao, Xin-miao Liang, Jia-wei Zhou

J Exp Med (2022) 219 (9): e20210998.

DOI: https://doi.org/10.1084/jem.20210998

Published: 25 July 2022

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Includes: Supplementary data

Journal Articles

IL-24 intrinsically regulates Th17 cell pathogenicity in mice

In Special Collection:

Cytokines Collection 2022

Christopher Sie, Ravi Kant, Christian Peter, Andreas Muschaweckh, Monika Pfaller, Lucy Nirschl, Helena Domínguez Moreno, Tereza Chadimová, Gildas Lepennetier, Tanja Kuhlmann, Rupert Öllinger, Thomas Engleitner, Roland Rad, Thomas Korn

J Exp Med (2022) 219 (8): e20212443.

DOI: https://doi.org/10.1084/jem.20212443

Published: 12 July 2022

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Includes: Supplementary data

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Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L.A. Nguyen, TianMeng Xu, Camila Pará, Yojiro Yamanaka, David A. Priestman, Frances M. Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R. Morales, Alexey V. Pshezhetsky

J Exp Med (2022) 219 (8): e20211860.

DOI: https://doi.org/10.1084/jem.20211860

Published: 15 June 2022

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Includes: Supplementary data

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Interleukin-4 receptor signaling modulates neuronal network activity

In Special Collection:

Cytokines Collection 2022

Nicholas Hanuscheck, Carine Thalman, Micaela Domingues, Samantha Schmaul, Muthuraman Muthuraman, Florian Hetsch, Manuela Ecker, Heiko Endle, Mohammadsaleh Oshaghi, Gianvito Martino, Tanja Kuhlmann, Katarzyna Bozek, Tim van Beers, Stefan Bittner, Jakob von Engelhardt, Johannes Vogt, Christina Francisca Vogelaar, Frauke Zipp

J Exp Med (2022) 219 (6): e20211887.

DOI: https://doi.org/10.1084/jem.20211887

Published: 19 May 2022

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Includes: Supplementary data

Journal Articles

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

In Special Collection:

Innate Immunity: From Basic Biology to Human Disease , Neuroscience Collection 2022

J Exp Med (2022) 219 (4): e20211121.

DOI: https://doi.org/10.1084/jem.20211121

Published: 09 March 2022

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Includes: Supplementary data

Journal Articles

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

J Exp Med (2022) 219 (3): e20211071.

DOI: https://doi.org/10.1084/jem.20211071

Published: 24 February 2022

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Includes: Supplementary data

Journal Articles

The gut–meningeal immune axis: Priming brain defense against the most likely invaders

In Special Collection:

JEM Mucosal Immunology 2022 , Neuroscience Collection 2022 , Neuroimmunology and Neurodegeneration

Rafael Di Marco Barros, Zachary Fitzpatrick, Menna R. Clatworthy

J Exp Med (2022) 219 (3): e20211520.

DOI: https://doi.org/10.1084/jem.20211520

Published: 23 February 2022

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Journal Articles

Neural control of immune cell trafficking

In Special Collection:

Neuroscience Collection 2022 , Neuroimmunology and Neurodegeneration

Scott N. Mueller

J Exp Med (2022) 219 (3): e20211604.

DOI: https://doi.org/10.1084/jem.20211604

Published: 23 February 2022

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Journal Articles

Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

In Special Collection:

Immunology Update Winter 2022 , Neuroimmunology and Neurodegeneration

Hemraj B. Dodiya, Holly L. Lutz, Ian Q. Weigle, Priyam Patel, Julia Michalkiewicz, Carlos J. Roman-Santiago, Can Martin Zhang, Yingxia Liang, Abhinav Srinath, Xulun Zhang, Jessica Xia, Monica Olszewski, Xiaoqiong Zhang, Matthew John Schipma, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, Sangram S. Sisodia

J Exp Med (2021) 219 (1): e20200895.

DOI: https://doi.org/10.1084/jem.20200895

Published: 02 December 2021

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Includes: Supplementary data

Journal Articles

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

Eva-Maria Frickel, Christopher A. Hunter

J Exp Med (2021) 218 (11): e20201314.

DOI: https://doi.org/10.1084/jem.20201314

Published: 20 October 2021

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Journal Articles

Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?

In Special Collection:

Neuroscience Collection 2021

Yun Chen, Marco Colonna

J Exp Med (2021) 218 (9): e20202717.

DOI: https://doi.org/10.1084/jem.20202717

Published: 22 July 2021

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Journal Articles

Functional immune cell–astrocyte interactions

In Special Collection:

Neuroscience Collection 2021

Liliana M. Sanmarco, Carolina M. Polonio, Michael A. Wheeler, Francisco J. Quintana

J Exp Med (2021) 218 (9): e20202715.

DOI: https://doi.org/10.1084/jem.20202715

Published: 22 July 2021

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2 3 4 5

NARROW

Engineering mighty microglia

Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

Targeting neuroinflammation in neuropathic pain and opioid use

Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice

Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma

The X factor in neurodegeneration

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis

IL-24 intrinsically regulates Th17 cell pathogenicity in mice

Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

Interleukin-4 receptor signaling modulates neuronal network activity

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

The gut–meningeal immune axis: Priming brain defense against the most likely invaders

Neural control of immune cell trafficking

Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?

Functional immune cell–astrocyte interactions

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