Search Results | Journal of Experimental Medicine

1-20 of 171

2 3 4 5

Sort by

Sort Order Select

Journal Articles

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Lestat R. Ali, Ana C. Garrido-Castro, Patrick J. Lenehan, Naima Bollenrucher, Courtney T. Stump, Michael Dougan, Shom Goel, Geoffrey I. Shapiro, Sara M. Tolaney, Stephanie K. Dougan

J Exp Med (2023) 220 (4): e20220729.

DOI: https://doi.org/10.1084/jem.20220729

Published: 23 January 2023

View article

Journal Articles

Tumor-derived OBP2A promotes prostate cancer castration resistance

Ji-Hak Jeong, Shangwei Zhong, Fuzhuo Li, Changhao Huang, Xueyan Chen, Qingqing Liu, Shoujiao Peng, HaJeung Park, You Mie Lee, Jasreman Dhillon, Jun-Li Luo

J Exp Med (2022) 220 (3): e20211546.

DOI: https://doi.org/10.1084/jem.20211546

Published: 22 December 2022

View article

Includes: Supplementary data

Journal Articles

γδIL17 under control

Guillem Sanchez Sanchez, David Vermijlen

J Exp Med (2022) 220 (2): e20221921.

DOI: https://doi.org/10.1084/jem.20221921

Published: 15 December 2022

View article

Journal Articles

Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

Akiko Nakayama, Kenneth Anthony Roquid, András Iring, Boris Strilic, Stefan Günther, Min Chen, Lee S. Weinstein, Stefan Offermanns

J Exp Med (2022) 220 (1): e20211628.

DOI: https://doi.org/10.1084/jem.20211628

Published: 14 November 2022

View article

Includes: Supplementary data

Journal Articles

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

J Exp Med (2022) 220 (1): e20202595.

DOI: https://doi.org/10.1084/jem.20202595

Published: 21 October 2022

View article

Includes: Supplementary data

Journal Articles

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

In Special Collection:

Immunology Update Winter 2023

Wenting Du, Rosa E. Menjivar, Katelyn L. Donahue, Padma Kadiyala, Ashley Velez-Delgado, Kristee L. Brown, Hannah R. Watkoske, Xi He, Eileen S. Carpenter, Christina V. Angeles, Yaqing Zhang, Marina Pasca di Magliano

J Exp Med (2022) 220 (1): e20220503.

DOI: https://doi.org/10.1084/jem.20220503

Published: 14 October 2022

View article

Includes: Supplementary data

Journal Articles

Eating away T cell responses in lung cancer

Roberto Ferrara, Luca Roz

J Exp Med (2022) 219 (12): e20221449.

DOI: https://doi.org/10.1084/jem.20221449

Published: 10 October 2022

View article

Journal Articles

DSTYK inhibition increases the sensitivity of lung cancer cells to T cell–mediated cytotoxicity

In Special Collection:

JEM Cancer Immunotherapy 2022

Karmele Valencia, Mirari Echepare, Álvaro Teijeira, Andrea Pasquier, Cristina Bértolo, Cristina Sainz, Ibon Tamayo, Beñat Picabea, Graziella Bosco, Roman Thomas, Jackeline Agorreta, José María López-Picazo, Joan Frigola, Ramon Amat, Alfonso Calvo, Enriqueta Felip, Ignacio Melero, Luis M. Montuenga

J Exp Med (2022) 219 (12): e20220726.

DOI: https://doi.org/10.1084/jem.20220726

Published: 28 September 2022

View article

Includes: Supplementary data

Journal Articles

Inhibition of GABA_A receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity

Cuiyu Zhang, Yuping Zhou, Junjie Zheng, Nannan Ning, Haining Liu, Wenyang Jiang, Xin Yu, Kun Mu, Yan Li, Wei Guo, Huili Hu, Jingxin Li, Dawei Chen

J Exp Med (2022) 219 (12): e20220541.

DOI: https://doi.org/10.1084/jem.20220541

Published: 20 September 2022

View article

Includes: Supplementary data

Journal Articles

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

In Special Collection:

JEM Cancer Immunotherapy 2022 , JEM Clinical Immunology Collection 2022 , Mechanisms and Models of Cancer 2022 Update

J Exp Med (2022) 219 (6): e20212169.

DOI: https://doi.org/10.1084/jem.20212169

Published: 23 May 2022

View article

Includes: Supplementary data

Journal Articles

Altered glycosylation in pancreatic cancer and beyond

In Special Collection:

Mechanisms and Models of Cancer 2022 Update

Jan C. Lumibao, Jacob R. Tremblay, Jasper Hsu, Dannielle D. Engle

J Exp Med (2022) 219 (6): e20211505.

DOI: https://doi.org/10.1084/jem.20211505

Published: 06 May 2022

View article

Journal Articles

Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET–rearranged thyroid cancer

J Exp Med (2022) 219 (6): e20210390.

DOI: https://doi.org/10.1084/jem.20210390

Published: 05 May 2022

View article

Includes: Supplementary data

Journal Articles

In vivo labeling reveals continuous trafficking of TCF-1⁺ T cells between tumor and lymphoid tissue

In Special Collection:

Lymphatic Vessels in Health and Disease 2022 , Mechanisms and Models of Cancer 2022 Update

Zhi Li, Zewen K. Tuong, Isaac Dean, Claire Willis, Fabrina Gaspal, Rémi Fiancette, Suaad Idris, Bethany Kennedy, John R. Ferdinand, Ana Peñalver, Mia Cabantous, Syed Murtuza Baker, Jeremy W. Fry, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Matthew R. Hepworth, Menna R. Clatworthy, David R. Withers

J Exp Med (2022) 219 (6): e20210749.

DOI: https://doi.org/10.1084/jem.20210749

Published: 26 April 2022

View article

Journal Articles

IL-17–induced HIF1α drives resistance to anti–PD-L1 via fibroblast-mediated immune exclusion

In Special Collection:

JEM Cancer Immunotherapy 2022 , JEM Mucosal Immunology 2022 , Mechanisms and Models of Cancer 2022 Update

Xing Chen, Junjie Zhao, Tomasz Herjan, Lingzi Hong, Yun Liao, Caini Liu, Kommireddy Vasu, Han Wang, Austin Thompson, Paul L. Fox, Brian R. Gastman, Xiao Li, Xiaoxia Li

J Exp Med (2022) 219 (6): e20210693.

DOI: https://doi.org/10.1084/jem.20210693

Published: 07 April 2022

View article

Includes: Supplementary data

Journal Articles

Iron out KRAS-driven cancer

Guang Lei, Boyi Gan

J Exp Med (2022) 219 (4): e20212166.

DOI: https://doi.org/10.1084/jem.20212166

Published: 09 March 2022

View article

Journal Articles

Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors

In Special Collection:

Mechanisms and Models of Cancer 2022 Update

Honglin Jiang, Ryan K. Muir, Ryan L. Gonciarz, Adam B. Olshen, Iwei Yeh, Byron C. Hann, Ning Zhao, Yung-hua Wang, Spencer C. Behr, James E. Korkola, Michael J. Evans, Eric A. Collisson, Adam R. Renslo

J Exp Med (2022) 219 (4): e20210739.

DOI: https://doi.org/10.1084/jem.20210739

Published: 09 March 2022

View article

Includes: Supplementary data

Journal Articles

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

In Special Collection:

JEM Cancer Immunotherapy 2022 , JEM Cancer Collection 2022 , JEM Immunology Collection 2022 , 2022: The Year in Experimental Medicine

J Exp Med (2021) 219 (2): e20201966.

DOI: https://doi.org/10.1084/jem.20201966

Published: 22 December 2021

View article

Journal Articles

Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

J Exp Med (2021) 219 (1): e20201039.

DOI: https://doi.org/10.1084/jem.20201039

Published: 17 December 2021

View article

Includes: Supplementary data

Journal Articles

WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway

J Exp Med (2021) 219 (1): e20210789.

DOI: https://doi.org/10.1084/jem.20210789

Published: 26 November 2021

View article

Journal Articles

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy

In Special Collection:

JEM Cancer Collection 2022 , 2022: The Year in Experimental Medicine

Bassem D. Khalil, Roberto Sanchez, Tasrina Rahman, Carolina Rodriguez-Tirado, Stefan Moritsch, Alba Rodriguez Martinez, Brett Miles, Eduardo Farias, Mihaly Mezei, Ana Rita Nobre, Deepak Singh, Nupura Kale, Karl Christoph Sproll, Maria Soledad Sosa, Julio A. Aguirre-Ghiso

J Exp Med (2021) 219 (1): e20210836.

DOI: https://doi.org/10.1084/jem.20210836

Published: 23 November 2021

View article

Includes: Supplementary data

2 3 4 5

NARROW

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Tumor-derived OBP2A promotes prostate cancer castration resistance

γδIL17 under control

Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

Eating away T cell responses in lung cancer

DSTYK inhibition increases the sensitivity of lung cancer cells to T cell–mediated cytotoxicity

Inhibition of GABA_A receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Altered glycosylation in pancreatic cancer and beyond

Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET–rearranged thyroid cancer

In vivo labeling reveals continuous trafficking of TCF-1⁺ T cells between tumor and lymphoid tissue

IL-17–induced HIF1α drives resistance to anti–PD-L1 via fibroblast-mediated immune exclusion

Iron out KRAS-driven cancer

Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy

Email alerts

Email alerts

This Feature Is Available To Subscribers Only