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Regulatory T cells suppress CD4⁺ effector T cell activation by controlling protein synthesis

Lomon So, Kazushige Obata-Ninomiya, Alex Hu, Virginia S. Muir, Ayako Takamori, Jing Song, Jane H. Buckner, Ram Savan, Steven F. Ziegler

J Exp Med (2023) 220 (3): e20221676.

DOI: https://doi.org/10.1084/jem.20221676

Published: 04 January 2023

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Includes: Supplementary data

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Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

J Exp Med (2022) 220 (2): e20220386.

DOI: https://doi.org/10.1084/jem.20220386

Published: 01 December 2022

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Includes: Supplementary data

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Toward an understanding of allogeneic conflict in pregnancy and transplantation

Samarth S. Durgam, Maria-Luisa Alegre, Anita S. Chong

J Exp Med (2022) 219 (5): e20211493.

DOI: https://doi.org/10.1084/jem.20211493

Published: 13 April 2022

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Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance

Gabrielle Rizzuto, Adrian Erlebacher

J Exp Med (2022) 219 (5): e20211515.

DOI: https://doi.org/10.1084/jem.20211515

Published: 13 April 2022

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Monocytic MDSCs homing to thymus contribute to age-related CD8⁺ T cell tolerance of HBV

J Exp Med (2022) 219 (4): e20211838.

DOI: https://doi.org/10.1084/jem.20211838

Published: 07 March 2022

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Includes: Supplementary data

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mTEC damage risks immune recovery

Yousuke Takahama

J Exp Med (2021) 219 (2): e20212326.

DOI: https://doi.org/10.1084/jem.20212326

Published: 17 December 2021

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Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD

Abdullah S. Alawam, Emilie J. Cosway, Kieran D. James, Beth Lucas, Andrea Bacon, Sonia M. Parnell, Andrea J. White, William E. Jenkinson, Graham Anderson

J Exp Med (2021) 219 (2): e20211239.

DOI: https://doi.org/10.1084/jem.20211239

Published: 15 December 2021

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Inhibitory pattern recognition receptors

Matevž Rumpret, Helen J. von Richthofen, Victor Peperzak, Linde Meyaard

J Exp Med (2021) 219 (1): e20211463.

DOI: https://doi.org/10.1084/jem.20211463

Published: 14 December 2021

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“P₂RY₈-son” break of tolerance promotes SLE

Maud Tusseau, Alexandre Belot

J Exp Med (2021) 219 (1): e20211972.

DOI: https://doi.org/10.1084/jem.20211972

Published: 13 December 2021

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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

In Special Collection:

JEM Immunology Collection 2022

Emma L. Lewis, Rong Xu, Jean-Christophe Beltra, Shin Foong Ngiow, Jordana Cohen, Rahul Telange, Alexander Crane, Deirdre Sawinski, E. John Wherry, Paige M. Porrett

J Exp Med (2021) 219 (1): e20201599.

DOI: https://doi.org/10.1084/jem.20201599

Published: 09 December 2021

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Includes: Supplementary data

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Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation

J Exp Med (2021) 218 (11): e20201076.

DOI: https://doi.org/10.1084/jem.20201076

Published: 03 September 2021

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Includes: Supplementary data

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MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites

Robin S. Lindsay, Jennifer C. Whitesell, Kristen E. Dew, Erika Rodriguez, Adam M. Sandor, Dayna Tracy, Seth F. Yannacone, Brittany N. Basta, Jordan Jacobelli, Rachel S. Friedman

J Exp Med (2021) 218 (10): e20200464.

DOI: https://doi.org/10.1084/jem.20200464

Published: 20 August 2021

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Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity

Xinying Zong, Xiaolei Hao, Beisi Xu, Jeremy Chase Crawford, Shaela Wright, Jun Li, Yang Zhang, Lu Bai, Minghong He, Menglin Jiang, Yiping Fan, Jon P. Connelly, Shondra M. Pruett-Miller, Hartmut Berns, Laura Janke, Chunliang Li, Yongqiang Feng

J Exp Med (2021) 218 (8): e20202415.

DOI: https://doi.org/10.1084/jem.20202415

Published: 04 June 2021

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Includes: Supplementary data

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Cbl-b deficiency prevents functional but not phenotypic T cell anergy

In Special Collection:

JEM Immunology Collection 2022

Trang T.T. Nguyen, Zhi-En Wang, Lin Shen, Andrew Schroeder, Walter Eckalbar, Arthur Weiss

J Exp Med (2021) 218 (7): e20202477.

DOI: https://doi.org/10.1084/jem.20202477

Published: 11 May 2021

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Includes: Supplementary data

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Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration

David E.J. Klawon, Dana C. Gilmore, John D. Leonard, Christine H. Miller, Jaime L. Chao, Matthew T. Walker, Ryan K. Duncombe, Kenneth S. Tung, Erin J. Adams, Peter A. Savage

J Exp Med (2021) 218 (6): e20200701.

DOI: https://doi.org/10.1084/jem.20200701

Published: 29 April 2021

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Journal Articles

Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity

In Special Collection:

Cardiovascular Biology 2021 , Lipid Mediators in Immunity

Guillaume Harlé, Camille Kowalski, Juan Dubrot, Dale Brighouse, Gaëlle Clavel, Robert Pick, Natacha Bessis, Jennifer Niven, Christoph Scheiermann, Monique Gannagé, Stéphanie Hugues

J Exp Med (2021) 218 (6): e20201776.

DOI: https://doi.org/10.1084/jem.20201776

Published: 16 April 2021

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Journal Articles

The pleiotropic roles of leptin in metabolism, immunity, and cancer

Paola de Candia, Francesco Prattichizzo, Silvia Garavelli, Carlo Alviggi, Antonio La Cava, Giuseppe Matarese

J Exp Med (2021) 218 (5): e20191593.

DOI: https://doi.org/10.1084/jem.20191593

Published: 15 April 2021

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Journal Articles

From antibody specificity to T cell recognition

Hye-Jung Kim, Harvey Cantor

J Exp Med (2021) 218 (4): e20202038.

DOI: https://doi.org/10.1084/jem.20202038

Published: 12 March 2021

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Journal Articles

αβγδ T cells play a vital role in fetal human skin development and immunity

René Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kölz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Wolfgang Eppel, Adelheid Elbe-Bürger

J Exp Med (2021) 218 (4): e20201189.

DOI: https://doi.org/10.1084/jem.20201189

Published: 09 February 2021

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Includes: Supplementary data

Journal Articles

ZFP91 is required for the maintenance of regulatory T cell homeostasis and function

Aiting Wang, Lei Ding, Zhongqiu Wu, Rui Ding, Xiao-Lu Teng, Feixiang Wang, Zhilin Hu, Lei Chen, Xiaoyan Yu, Qiang Zou

J Exp Med (2020) 218 (2): e20201217.

DOI: https://doi.org/10.1084/jem.20201217

Published: 23 December 2020

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NARROW

Regulatory T cells suppress CD4⁺ effector T cell activation by controlling protein synthesis

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

Toward an understanding of allogeneic conflict in pregnancy and transplantation

Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance

Monocytic MDSCs homing to thymus contribute to age-related CD8⁺ T cell tolerance of HBV

mTEC damage risks immune recovery

Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD

Inhibitory pattern recognition receptors

“P₂RY₈-son” break of tolerance promotes SLE

NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation

MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites

Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity

Cbl-b deficiency prevents functional but not phenotypic T cell anergy

Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration

Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity

The pleiotropic roles of leptin in metabolism, immunity, and cancer

From antibody specificity to T cell recognition

αβγδ T cells play a vital role in fetal human skin development and immunity

ZFP91 is required for the maintenance of regulatory T cell homeostasis and function

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