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STAT3 regulates CD8⁺ T cell differentiation and functions in cancer and acute infection

Qinli Sun, Xiaohong Zhao, Ruifeng Li, Dingfeng Liu, Birui Pan, Bowen Xie, Xinxin Chi, Dongli Cai, Peng Wei, Wei Xu, Kun Wei, Zixuan Zhao, Yujie Fu, Ling Ni, Chen Dong

J Exp Med (2023) 220 (4): e20220686.

DOI: https://doi.org/10.1084/jem.20220686

Published: 23 January 2023

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Includes: Supplementary data

Journal Articles

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Lestat R. Ali, Ana C. Garrido-Castro, Patrick J. Lenehan, Naima Bollenrucher, Courtney T. Stump, Michael Dougan, Shom Goel, Geoffrey I. Shapiro, Sara M. Tolaney, Stephanie K. Dougan

J Exp Med (2023) 220 (4): e20220729.

DOI: https://doi.org/10.1084/jem.20220729

Published: 23 January 2023

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Journal Articles

Microbiome influencers of checkpoint blockade–associated toxicity

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM)

Yinghong Wang, Robert R. Jenq, Jennifer A. Wargo, Stephanie S. Watowich

J Exp Med (2023) 220 (3): e20220948.

DOI: https://doi.org/10.1084/jem.20220948

Published: 09 January 2023

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Journal Articles

γδIL17 under control

Guillem Sanchez Sanchez, David Vermijlen

J Exp Med (2022) 220 (2): e20221921.

DOI: https://doi.org/10.1084/jem.20221921

Published: 15 December 2022

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PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

In Special Collection:

Immunology Update Winter 2023

Sarah C. Edwards, Ann Hedley, Wilma H.M. Hoevenaar, Robert Wiesheu, Teresa Glauner, Anna Kilbey, Robin Shaw, Katerina Boufea, Nizar Batada, Shinya Hatano, Yasunobu Yoshikai, Karen Blyth, Crispin Miller, Kristina Kirschner, Seth B. Coffelt

J Exp Med (2022) 220 (2): e20211431.

DOI: https://doi.org/10.1084/jem.20211431

Published: 07 December 2022

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Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Immunology Update Winter 2023

J Exp Med (2022) 220 (2): e20221333.

DOI: https://doi.org/10.1084/jem.20221333

Published: 11 November 2022

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Journal Articles

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8⁺ T cells

Tarun Tyagi, Kanika Jain, Timur O. Yarovinsky, Michael Chiorazzi, Jing Du, Cecilia Castro, Jules Griffin, Asawari Korde, Kathleen A. Martin, Shervin S. Takyar, Richard A. Flavell, Abhijit A. Patel, John Hwa

J Exp Med (2022) 220 (1): e20212218.

DOI: https://doi.org/10.1084/jem.20212218

Published: 28 October 2022

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WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

In Special Collection:

Immunology Update Winter 2023

Wenting Du, Rosa E. Menjivar, Katelyn L. Donahue, Padma Kadiyala, Ashley Velez-Delgado, Kristee L. Brown, Hannah R. Watkoske, Xi He, Eileen S. Carpenter, Christina V. Angeles, Yaqing Zhang, Marina Pasca di Magliano

J Exp Med (2022) 220 (1): e20220503.

DOI: https://doi.org/10.1084/jem.20220503

Published: 14 October 2022

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Includes: Supplementary data

Journal Articles

Eating away T cell responses in lung cancer

Roberto Ferrara, Luca Roz

J Exp Med (2022) 219 (12): e20221449.

DOI: https://doi.org/10.1084/jem.20221449

Published: 10 October 2022

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Journal Articles

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

J Exp Med (2022) 219 (12): e20211476.

DOI: https://doi.org/10.1084/jem.20211476

Published: 30 September 2022

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An engineered concealed IL-15-R elicits tumor-specific CD8⁺T cell responses through PD-1-cis delivery

In Special Collection:

JEM Cancer Immunotherapy 2022

Jiao Shen, Zhuangzhi Zou, Jingya Guo, Yueqi Cai, Diyuan Xue, Yong Liang, Wenyan Wang, Hua Peng, Yang-Xin Fu

J Exp Med (2022) 219 (12): e20220745.

DOI: https://doi.org/10.1084/jem.20220745

Published: 27 September 2022

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Bringing natural killer cells to the clinic

Laura Chiossone, Eric Vivier

J Exp Med (2022) 219 (10): e20220830.

DOI: https://doi.org/10.1084/jem.20220830

Published: 06 September 2022

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Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

In Special Collection:

Hematology 2022

Yu Rebecca Miao, Kaushik Thakkar, Can Cenik, Dadi Jiang, Kazue Mizuno, Chenjun Jia, Caiyun Grace Li, Hongjuan Zhao, Anh Diep, Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-sze Leung, Albert C. Koong, Amato J. Giaccia

J Exp Med (2022) 219 (9): e20220214.

DOI: https://doi.org/10.1084/jem.20220214

Published: 26 July 2022

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Journal Articles

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

In Special Collection:

JEM Cancer Immunotherapy 2022

Alessandro Camponeschi, Kathrin Kläsener, Timothy Sundell, Christina Lundqvist, Paul T. Manna, Negar Ayoubzadeh, Martina Sundqvist, Katrin Thorarinsdottir, Mariele Gatto, Marcella Visentini, Karin Önnheim, Alaitz Aranburu, Huamei Forsman, Olov Ekwall, Linda Fogelstrand, Inger Gjertsson, Michael Reth, Inga-Lill Mårtensson

J Exp Med (2022) 219 (9): e20220201.

DOI: https://doi.org/10.1084/jem.20220201

Published: 12 July 2022

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Journal Articles

Inherited TNFSF9 deficiency causes broad Epstein–Barr virus infection with EBV⁺ smooth muscle tumors

In Special Collection:

Mechanisms and Models of Cancer 2022 Update

Benjamin Fournier, Akihiro Hoshino, Julie Bruneau, Camille Bachelet, Mathieu Fusaro, Roman Klifa, Romain Lévy, Christelle Lenoir, Claire Soudais, Capucine Picard, Stéphane Blanche, Martin Castelle, Despina Moshous, Thierry Molina, Anne-Sophie Defachelles, Bénédicte Neven, Sylvain Latour

J Exp Med (2022) 219 (7): e20211682.

DOI: https://doi.org/10.1084/jem.20211682

Published: 03 June 2022

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Includes: Supplementary data

Journal Articles

CD4⁺ T helper 2 cells suppress breast cancer by inducing terminal differentiation

In Special Collection:

JEM Cancer Immunotherapy 2022

Margherita Boieri, Anna Malishkevich, Ranya Guennoun, Emanuela Marchese, Sanne Kroon, Kathryn E. Trerice, Mary Awad, Jong Ho Park, Sowmya Iyer, Johannes Kreuzer, Wilhelm Haas, Miguel N. Rivera, Shadmehr Demehri

J Exp Med (2022) 219 (7): e20201963.

DOI: https://doi.org/10.1084/jem.20201963

Published: 03 June 2022

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Includes: Supplementary data

Journal Articles

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

In Special Collection:

JEM Cancer Immunotherapy 2022 , JEM Clinical Immunology Collection 2022 , Mechanisms and Models of Cancer 2022 Update

J Exp Med (2022) 219 (6): e20212169.

DOI: https://doi.org/10.1084/jem.20212169

Published: 23 May 2022

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Includes: Supplementary data

Journal Articles

Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint

Mandy J. McGeachy

J Exp Med (2022) 219 (6): e20220444.

DOI: https://doi.org/10.1084/jem.20220444

Published: 18 May 2022

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Journal Articles

Neutrophil phenotypes and functions in cancer: A consensus statement

In Special Collection:

JEM Cancer Immunotherapy 2022 , Mechanisms and Models of Cancer 2022 Update

J Exp Med (2022) 219 (6): e20220011.

DOI: https://doi.org/10.1084/jem.20220011

Published: 06 May 2022

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Journal Articles

In vivo labeling reveals continuous trafficking of TCF-1⁺ T cells between tumor and lymphoid tissue

In Special Collection:

Lymphatic Vessels in Health and Disease 2022 , Mechanisms and Models of Cancer 2022 Update

Zhi Li, Zewen K. Tuong, Isaac Dean, Claire Willis, Fabrina Gaspal, Rémi Fiancette, Suaad Idris, Bethany Kennedy, John R. Ferdinand, Ana Peñalver, Mia Cabantous, Syed Murtuza Baker, Jeremy W. Fry, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Matthew R. Hepworth, Menna R. Clatworthy, David R. Withers

J Exp Med (2022) 219 (6): e20210749.

DOI: https://doi.org/10.1084/jem.20210749

Published: 26 April 2022

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NARROW

STAT3 regulates CD8⁺ T cell differentiation and functions in cancer and acute infection

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

Microbiome influencers of checkpoint blockade–associated toxicity

γδIL17 under control

PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8⁺ T cells

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

Eating away T cell responses in lung cancer

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

An engineered concealed IL-15-R elicits tumor-specific CD8⁺T cell responses through PD-1-cis delivery

Bringing natural killer cells to the clinic

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

Inherited TNFSF9 deficiency causes broad Epstein–Barr virus infection with EBV⁺ smooth muscle tumors

CD4⁺ T helper 2 cells suppress breast cancer by inducing terminal differentiation

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint

Neutrophil phenotypes and functions in cancer: A consensus statement

In vivo labeling reveals continuous trafficking of TCF-1⁺ T cells between tumor and lymphoid tissue

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