Conductance changes associated with the response of the squid giant axon have been studied at two temperature ranges (26–27°C.; 9–10°C.) and with modified concentrations of sodium and potassium in the medium. The phase of "initial after-conductance," during which the membrane resistance increases above the resting value, is smaller at the lower temperature. At both temperature ranges it is diminished by doubling K+ in the medium and enhanced by removal of K+. Halving the Na+ of the medium also enhances this phase when K+ is absent, but not otherwise. The time course of the conductance changes alters in form with changes of the external medium. These changes indicate independent changes in the complex of ionic events associated with the response. The experiments therefore confirm the reality of the phase of increased membrane resistance. The magnitude of this change appears to be considerable and requires a transient decrease in the mobility and/or concentration of ions in the membrane. The possible cause of this decrease is discussed.
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November 20 1957
THE EFFECT OF TEMPERATURE, POTASSIUM, AND SODIUM ON THE CONDUCTANCE CHANGE ACCOMPANYING THE ACTION POTENTIAL IN THE SQUID GIANT AXON
E. Amatniek,
E. Amatniek
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
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W. Freygang,
W. Freygang
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
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H. Grundfest,
H. Grundfest
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
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G. Kiebel,
G. Kiebel
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
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A. Shanes
A. Shanes
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
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E. Amatniek
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
W. Freygang
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
H. Grundfest
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
G. Kiebel
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
A. Shanes
From the National Institute of Mental Health and the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York; and the Marine Biological Laboratory, Woods Hole
Received:
April 15 1957
Online ISSN: 1540-7748
Print ISSN: 0022-1295
Copyright, 1957, by The Rockefeller Institute for Medical Research
1957
J Gen Physiol (1957) 41 (2): 333–342.
Article history
Received:
April 15 1957
Citation
E. Amatniek, W. Freygang, H. Grundfest, G. Kiebel, A. Shanes; THE EFFECT OF TEMPERATURE, POTASSIUM, AND SODIUM ON THE CONDUCTANCE CHANGE ACCOMPANYING THE ACTION POTENTIAL IN THE SQUID GIANT AXON . J Gen Physiol 20 November 1957; 41 (2): 333–342. doi: https://doi.org/10.1085/jgp.41.2.333
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