Thyroxine has been shown to accelerate the synthesis of carbamyl phosphate synthetase in the liver of Rana catesbeiana. Stimulation of carbamyl phosphate synthetase synthesis by thyroxine appears to be relatively specific because of the following observations: (1) succinoxidase activity decreased during the time that carbamyl phosphate synthetase increased; (2) liver catalase responded more slowly than carbamyl phosphate synthetase to thyroxine; (3) the ratio of biochemical changes/morphological changes was greatly altered during thyroxine-induced metamorphosis. The relationships between the concentration of thyroxine and (1) temperature; (2) duration of exposure of the tadpole to thyroxine; and (3) the activity of carbamyl phosphate synthetase during the induced synthesis of carbamyl phosphate synthetase by thyroxine are discussed. Chloramphenicol and thiouracil partly counteracted the effect of thyroxine on the synthesis of carbamyl phosphate synthetase.
Article|
March 01 1960
Biochemical Studies on Amphibian Metamorphosis : I. The effect of thyroxine on protein synthesis in the tadpole
Woon Ki Paik,
Woon Ki Paik
From the Department of Physiological Chemistry, Service Memorial Institutes, University of Wisconsin, Madison
Search for other works by this author on:
Philip P. Cohen
Philip P. Cohen
From the Department of Physiological Chemistry, Service Memorial Institutes, University of Wisconsin, Madison
Search for other works by this author on:
Woon Ki Paik
From the Department of Physiological Chemistry, Service Memorial Institutes, University of Wisconsin, Madison
Philip P. Cohen
From the Department of Physiological Chemistry, Service Memorial Institutes, University of Wisconsin, Madison
Received:
June 05 1959
Online ISSN: 1540-7748
Print ISSN: 0022-1295
Copyright, 1960, by The Rockefeller Institute
1960
J Gen Physiol (1960) 43 (4): 683–696.
Article history
Received:
June 05 1959
Citation
Woon Ki Paik, Philip P. Cohen; Biochemical Studies on Amphibian Metamorphosis : I. The effect of thyroxine on protein synthesis in the tadpole . J Gen Physiol 1 March 1960; 43 (4): 683–696. doi: https://doi.org/10.1085/jgp.43.4.683
Download citation file: