This Review discusses ion channel expression and function in immune cells, residential non-immune cells and neuroimmune interactions in the gut, and how ion channels contribute to the maintenance of intestinal immune homeostasis and generation of autoimmune disorders under pathological conditions.
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation
We demonstrate that ASIC1a activates intermediate- and small-conductance Ca2+-activated K+ channels, which are essential mediators of endothelium-dependent hyperpolarization and vasodilation in mesenteric resistance arteries. Collectively, these data provide novel evidence that ASIC1a is an important contributor to endothelium-dependent vasodilation.
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation
The muscle regulatory protein tropomyosin relocates on thin filaments as the myosin motor binds to and releases from actin. We show that amino acid side chains at the tip of the myosin motor are critical for optimal tropomyosin repositioning.