Issues

Cover picture: Probing the topology of the pore-forming toxin Cry1Aa of the bacterium B. thuringiensis using fluorescence spectroscopy in planar lipid bilayer. (Top left) Schematic of the setup that allows imaging the planar lipid bilayer. (Top right) Crystal structure of Cry1Aa with the pore-forming domain I shown in green. (Bottom) Principle of the FRET assay with a donor attached to the toxin and a voltage-dependent acceptor in the membrane (see article by Groulx et al., 497–513).