Issues

Cover picture: (Left) The grand canonical Monte Carlo Brownian dynamics (GCMC/BD) system used to simulate ion permeation through molecular dynamics–equilibrated and non-equilibrated structural models of connexin-26 (Cx26) hemichannels. (Right) Depiction of sites at which charges were changed in the GCMC/BD studies to mimic the effects of previously reported MS-identified Cx26 protein modifications. Blue, N-acetylation of Met1; red, acetylation of lysine residue (K15) in the NT; green, acetylation of six internal lysine residues in CL; orange, γ-carboxylation of three glutamates (see article by Kwon et al., 475–493).