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1 January 2012
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Cover Image
Cover Image
Cover picture: Light exposure (chromophore-assisted light inactivation [CALI]) destroys aquaporin-4 (AQP4) water channels in an AQP4–Killer Red (KR) chimera. A neuromyelitis optica AQP4 autoantibody (NMO-IgG, green) binds to AQP4 in cell membranes. After AQP4 destruction by CALI, NMO-IgG binding is greatly reduced. As a control, NMO-IgG binding is not reduced when KR is expressed in cytoplasm rather than conjugated to AQP4 (see tutorial research article by Baumgart et al., 83–91).
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ISSN 0022-1295
EISSN 1540-7748
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