Issues

Cover picture: Intracellular TEA⁺ and NMG⁺ ions occupying the cavity of Kv1.2 channels stabilize the open state. The investigation by Goodchild et al. in this issue shows that ions in the open channel pore, including K⁺, are more than mere passengers. By exerting a resistance to pore closure and subsequent voltage sensor return, the presence of ions fundamentally modulates the gating of the channel (see article by Goodchild et al., 495–511).