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Cover Image
Cover Image
Cover picture: Morphological arrangement of two sets of ryanodine receptors (RyRs) in the triads of 3-d-old zebrafish skeletal muscle. One set (yellow) is positioned between the T-tubules and the sarcoplasmic reticulum, and the second (purple) is offset to the side. Morpholino silencing of RyR3 results in the almost complete disappearance of the second set and of readily detectable Ca2+ sparks in isolated myocytes (see research article by Perni et al., 173–184).
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Generally Physiological
Commentary
Article
Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle
RyR3 is the major component of parajunctional feet in skeletal muscle and the main ryanodine receptor mediating Ca2+ sparks.
Positions of the cytoplasmic end of BK α S0 helix relative to S1–S6 and of β1 TM1 and TM2 relative to S0–S6
The BK β1 subunit displaces the unique S0 transmembrane helix on the intracellular side of BK α but not on the extracellular side, thereby altering its path through the membrane.
Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions
A glutamate at position 290 in the human Kv7.1 S5-pore linker is required for its inhibition by high concentrations of extracellular potassium.
Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation
Rhodopsin kinase and its calcium-dependent inhibitor recoverin regulate decay of light-activated phosphodiesterase activity, enabling rods to respond rapidly to changes in light intensity in the presence of background light.
Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity
The serotonin mediating autoinhibition of neurons in the raphe nucleus is released from a nonvesicular pool.
Correction
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