Super-relaxation is a state of myosin in which ATP turnover is very slow, conserving energy in relaxed muscle. This work discusses the molecular interactions underlying super- and hyper-relaxation and how these are modulated in normal muscle physiology and disease.
Millet et al. show that the C. elegans orthologue of the PIEZO family, PEZO-1, is a mechanosensitive ion channel involved in food sensation and in regulating pharyngeal function in the nematode.
The Donnan-dominated resting state of skeletal muscle fibers contributes to resilience and longevity in dystrophic fibers
Morris et al. use a computational model of Pump-Leak/Donnan ion homeostasis to suggest that the Donnan dominated steady-state of skeletal muscle fibers underpins their longevity in the face of the structural and metabolic injuries incurred with Duchenne muscular dystrophy.
A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels
Chen et al. computationally model the open conformation of the hASIC1a channel to predict that mutations that eliminate channel selectivity cause a widening of the GAS belt. Their findings implicate the GAS belt diameter in channel kinetics and ion selectivity.