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JGP study shows that the electrical properties of the retinal pigment epithelium are influenced by connexin-based gap junctions and hemichannels.

Commentary

Brette, Le Guennec, and Thireau discuss recent findings on evolutionary cardiac electrophysiology.

Articles

Cells in the retinal pigment epithelium are coupled through a dense network of Cx43-based gap junctions. Fadjukov et al. show that both gap junctions and Cx43 hemichannels make substantial contributions to the input resistance of these electrically active cells.

Dai uses FRET spectroscopy to show that the epilepsy-related potassium channels KCNQ2/3 are recruited to lipid-raft membrane domains to form a signaling complex with the Alzheimer’s disease–related protein BACE1, a process that is dependent on the palmitoylation of BACE1.

The Burmese python is an excellent model of extreme biology which exhibits dramatic metabolic responses following consumption of a large meal. Magida et al. uncover a novel adaptation of hepatic metabolism and cellular signaling in the postprandial Burmese python liver.

Communications

Rohaim and colleagues present a strategy to generate synthetic recombinant antibody fragments (sFabs) for structural biology and studies of K+ channels. These sFabs perform comparably to traditional Fabs but are easier to produce.

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