Issues
Review
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling
Guarina et al. discuss recent findings suggesting that the high reproducibility of cardiac contraction emerges from high Ca2+ signaling variability at multiple levels due to stochastic fluctuations in multiple processes in time and space, but manifests as reliable Ca2+ transients during EC coupling.
Article
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
CPVT-linked RYR2 mutations are prone to induce spontaneous Ca2+ release from the ER, which is associated with arrhythmias. Kurebayashi et al. used experiments and simulations to explore the mechanisms relating cytosolic Ca2+-dependent activity by RYR2 mutations and spontaneous Ca2+ release.
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling
Xue et al. show that alteration of the Ca2+ clock by a mechanism involving CaMKII hypoactivation contributes to depression of the intrinsic pacemaker function of the sinoatrial node (SAN) in a mouse model of heart failure.
A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers
Barclay and Launikonis developed a mathematical model to quantify the cycling of Ca2+ within muscle cells and the heat produced by that process. That heat contributes to the resting heat production of muscles and thus to the maintenance of body temperature.
Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence
Muscle junctophilins 1 and 2 and neuronal junctophilins 3 and 4 differ in sequence and in interactions with RYR1. Junctophilin 2 has been shown to support voltage-induced calcium release. Perni and Beam show that junctophilins 1 and 3 also support such a release, but that junctophilin 4 does not.
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1
El Ghaleb et al. analyzed the effects of the γ1 subunit on current properties and expression of the adult (CaV1.1a) and embryonic (CaV1.1e) calcium channel splice variants, demonstrating that γ1 reduces the current amplitude in a splicing-dependent manner.
Communication
Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers
This communication investigates the effect of extracellular BTP2 on electrically evoked Ca2+ release in intact skeletal muscle fibers. The results demonstrate that acute exposure to 10 μM BTP2 does not significantly affect the magnitude or kinetics of electrically evoked Ca2+ release.
Correction
Meeting Abstract
Sinus node dysfunction in heart failure is characterized by reduced CaMKII signaling: Calcium Signaling and Excitation-Contraction Coupling in Cardiac, Skeletal and Smooth Muscle
Mitochondrial calpain inhibition restores defective SR-mitochondrial crosstalk in CPVT rat myocytes: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Structural basis for diamide modulation of ryanodine receptor: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
SERCA2a gain of function in patient-derived R14Del hiPSC-CMs: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Mutant D96V calmodulin induces unexpected remodeling of cardiac nanostructure and physiology: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle
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