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Review

Excitation–Contraction Coupling

Guarina et al. discuss recent findings suggesting that the high reproducibility of cardiac contraction emerges from high Ca2+ signaling variability at multiple levels due to stochastic fluctuations in multiple processes in time and space, but manifests as reliable Ca2+ transients during EC coupling.

Article

Excitation–Contraction Coupling

CPVT-linked RYR2 mutations are prone to induce spontaneous Ca2+ release from the ER, which is associated with arrhythmias. Kurebayashi et al. used experiments and simulations to explore the mechanisms relating cytosolic Ca2+-dependent activity by RYR2 mutations and spontaneous Ca2+ release.

Excitation–Contraction Coupling

Xue et al. show that alteration of the Ca2+ clock by a mechanism involving CaMKII hypoactivation contributes to depression of the intrinsic pacemaker function of the sinoatrial node (SAN) in a mouse model of heart failure.

Excitation–Contraction Coupling

Barclay and Launikonis developed a mathematical model to quantify the cycling of Ca2+ within muscle cells and the heat produced by that process. That heat contributes to the resting heat production of muscles and thus to the maintenance of body temperature.

Excitation–Contraction Coupling

Muscle junctophilins 1 and 2 and neuronal junctophilins 3 and 4 differ in sequence and in interactions with RYR1. Junctophilin 2 has been shown to support voltage-induced calcium release. Perni and Beam show that junctophilins 1 and 3 also support such a release, but that junctophilin 4 does not.

Excitation–Contraction Coupling

El Ghaleb et al. analyzed the effects of the γ1 subunit on current properties and expression of the adult (CaV1.1a) and embryonic (CaV1.1e) calcium channel splice variants, demonstrating that γ1 reduces the current amplitude in a splicing-dependent manner.

Communication

Excitation–Contraction Coupling

This communication investigates the effect of extracellular BTP2 on electrically evoked Ca2+ release in intact skeletal muscle fibers. The results demonstrate that acute exposure to 10 μM BTP2 does not significantly affect the magnitude or kinetics of electrically evoked Ca2+ release.

Correction

Meeting Abstract

E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
E–C Coupling Meeting 2021
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