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Alfred L. George
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Journal Articles

Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties

Christopher H. Thompson, Franck Potet, Tatiana V. Abramova, Jean-Marc DeKeyser, Nora F. Ghabra, Carlos G. Vanoye, John J. Millichap, Alfred L. George, Jr
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (10): e202313375.
https://doi.org/10.1085/jgp.202313375
Published: 14 August 2023
View article titled, Epilepsy-associated <em>SCN2A</em> (Na<sub>V</sub>1.2) variants exhibit diverse and complex functional properties
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Includes: Supplementary data
Journal Articles

Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation

In Special Collection:
Cardiac Physiology 2021
Hannah A. Ledford, Seojin Park, Duncan Muir, Ryan L. Woltz, Lu Ren, Phuong T. Nguyen, Padmini Sirish, Wenying Wang, Choong-Ryoul Sihn, Alfred L. George, Jr., Björn C. Knollmann, Ebenezer N. Yamoah, Vladimir Yarov-Yarovoy, Xiao-Dong Zhang, Nipavan Chiamvimonvat
Journal: Journal of General Physiology
J Gen Physiol (2020) 152 (12): e202012667.
https://doi.org/10.1085/jgp.202012667
Published: 19 November 2020
View article titled, Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation
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Includes: Supplementary data
Journal Articles

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

Christopher H. Thompson, Roy Ben-Shalom, Kevin J. Bender, Alfred L. George, Jr.
Journal: Journal of General Physiology
J Gen Physiol (2020) 152 (3): e201912442.
https://doi.org/10.1085/jgp.201912442
Published: 29 January 2020
View article titled, Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy <em>SCN2A</em> variants
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Journal Articles

Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling

Carlos G. Vanoye, Jennifer D. Kunic, George R. Ehring, Alfred L. George, Jr.
Journal: Journal of General Physiology
J Gen Physiol (2013) 141 (2): 193–202.
https://doi.org/10.1085/jgp.201210919
Published: 28 January 2013
View article titled, Mechanism of sodium channel Na<sub>V</sub>1.9 potentiation by G-protein signaling
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Journal Articles

Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits

Carlos G. Vanoye, Richard C. Welch, Melissa A. Daniels, Lauren J. Manderfield, Andrew R. Tapper, Charles R. Sanders, Alfred L. George, Jr.
Journal: Journal of General Physiology
J Gen Physiol (2009) 134 (3): 207–217.
https://doi.org/10.1085/jgp.200910234
Published: 17 August 2009
View article titled, Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits
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Journal Articles

Single-channel Properties of Human NaV1.1 and Mechanism of Channel Dysfunction in SCN1A-associated Epilepsy

Carlos G. Vanoye, Christoph Lossin, Thomas H. Rhodes, Alfred L. George, Jr.
Journal: Journal of General Physiology
J Gen Physiol (2005) 127 (1): 1–14.
https://doi.org/10.1085/jgp.200509373
Published: 27 December 2005
View article titled, Single-channel Properties of Human Na<sub>V</sub>1.1 and Mechanism of Channel Dysfunction in <em>SCN1A</em>-associated Epilepsy
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Journal Articles

Extracellular Sodium Interacts with the HERG Channel at an Outer Pore Site

Franklin M. Mullins, Svetlana Z. Stepanovic, Reshma R. Desai, Alfred L. George, Jr., Jeffrey R. Balser
Journal: Journal of General Physiology
J Gen Physiol (2002) 120 (4): 517–537.
https://doi.org/10.1085/jgp.20028589
Published: 16 September 2002
View article titled, Extracellular Sodium Interacts with the HERG Channel at an Outer Pore Site
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Journal Articles

Mink Subdomains That Mediate Modulation of and Association with Kvlqt1

Andrew R. Tapper, Alfred L. George, Jr.
Journal: Journal of General Physiology
J Gen Physiol (2000) 116 (3): 379–390.
https://doi.org/10.1085/jgp.116.3.379
Published: 14 August 2000
View article titled, Mink Subdomains That Mediate Modulation of and Association with Kvlqt1
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Journal Articles

Role of Domain 4 in Sodium Channel Slow Inactivation

Nenad Mitrovic, Alfred L. George, Jr., Richard Horn
Journal: Journal of General Physiology
J Gen Physiol (2000) 115 (6): 707–718.
https://doi.org/10.1085/jgp.115.6.707
Published: 01 June 2000
View article titled, Role of Domain 4 in Sodium Channel Slow Inactivation
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Journal Articles

Independent Versus Coupled Inactivation in Sodium Channels : Role of the Domain 2 S4 Segment

Nenad Mitrovic, Alfred L. George, Jr., Richard Horn
Journal: Journal of General Physiology
J Gen Physiol (1998) 111 (3): 451–462.
https://doi.org/10.1085/jgp.111.3.451
Published: 01 March 1998
View article titled, Independent Versus Coupled Inactivation in Sodium Channels : <subtitle>Role of the Domain 2 S4 Segment </subtitle>
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Journal Articles

Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels

Christoph Fahlke, Christine Dürr, Alfred L. George, Jr.
Journal: Journal of General Physiology
J Gen Physiol (1997) 110 (5): 551–564.
https://doi.org/10.1085/jgp.110.5.551
Published: 01 November 1997
View article titled, Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels
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Journal Articles

Subunit Stoichiometry of Human Muscle Chloride Channels

Christoph Fahlke, Timothy Knittle, Christina A. Gurnett, Kevin P. Campbell, Alfred L. George, Jr.
Journal: Journal of General Physiology
J Gen Physiol (1997) 109 (1): 93–104.
https://doi.org/10.1085/jgp.109.1.93
Published: 01 January 1997
View article titled, Subunit Stoichiometry of Human Muscle Chloride Channels
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