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Journal Articles

Optimization of CFTR gating through the evolution of its extracellular loops

Márton A. Simon, László Csanády

J Gen Physiol (2023) 155 (4): e202213264.

DOI: https://doi.org/10.1085/jgp.202213264

Published: 01 February 2023

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Journal Articles

Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel

In Special Collection:

Ion Channels & Transporters in Immunity

Balázs Tóth, Iordan Iordanov, László Csanády

J Gen Physiol (2020) 152 (5): e201912533.

DOI: https://doi.org/10.1085/jgp.201912533

Published: 25 March 2020

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Journal Articles

CFTR gating: Invisible transitions made visible

László Csanády

J Gen Physiol (2017) 149 (4): 413–416.

DOI: https://doi.org/10.1085/jgp.201711777

Published: 06 March 2017

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Journal Articles

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate

Balázs Tóth, Iordan Iordanov, László Csanády

J Gen Physiol (2015) 145 (5): 419–430.

DOI: https://doi.org/10.1085/jgp.201511377

Published: 27 April 2015

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Includes: Supplementary data

Journal Articles

Structure–activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects

László Csanády, Beáta Töröcsik

J Gen Physiol (2014) 144 (4): 321–336.

DOI: https://doi.org/10.1085/jgp.201411246

Published: 29 September 2014

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Includes: Supplementary data

Journal Articles

Catalyst-like modulation of transition states for CFTR channel opening and closing: New stimulation strategy exploits nonequilibrium gating

László Csanády, Beáta Töröcsik

J Gen Physiol (2014) 143 (2): 269–287.

DOI: https://doi.org/10.1085/jgp.201311089

Published: 13 January 2014

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Includes: Supplementary data

Journal Articles

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

László Csanády, Csaba Mihályi, Andras Szollosi, Beáta Töröcsik, Paola Vergani

J Gen Physiol (2013) 142 (1): 61–73.

DOI: https://doi.org/10.1085/jgp.201210954

Published: 10 June 2013

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Includes: Supplementary data

Journal Articles

Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

Andras Szollosi, Daniella R. Muallem, László Csanády, Paola Vergani

J Gen Physiol (2011) 137 (6): 549–562.

DOI: https://doi.org/10.1085/jgp.201110608

Published: 16 May 2011

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Includes: Supplementary data

Journal Articles

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2

Andras Szollosi, Paola Vergani, László Csanády

J Gen Physiol (2010) 136 (4): 407–423.

DOI: https://doi.org/10.1085/jgp.201010434

Published: 27 September 2010

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Includes: Supplementary data

Journal Articles

Degenerate ABC composite site is stably glued together by trapped ATP

László Csanády

J Gen Physiol (2010) 135 (5): 395–398.

DOI: https://doi.org/10.1085/jgp.201010443

Published: 26 April 2010

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Journal Articles

Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanisms

László Csanády

J Gen Physiol (2009) 134 (2): 129–136.

DOI: https://doi.org/10.1085/jgp.200910268

Published: 27 July 2009

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Journal Articles

Four Ca²⁺ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate

László Csanády, Beáta Törőcsik

J Gen Physiol (2009) 133 (2): 189–203.

DOI: https://doi.org/10.1085/jgp.200810109

Published: 26 January 2009

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Includes: Supplementary data

Journal Articles

Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains

László Csanády, Kim W. Chan, Donna Seto-Young, David C. Kopsco, Angus C. Nairn, David C. Gadsby

J Gen Physiol (2000) 116 (3): 477–500.

DOI: https://doi.org/10.1085/jgp.116.3.477

Published: 28 August 2000

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Includes: Supplementary data

Journal Articles

Severed Molecules Functionally Define the Boundaries of the Cystic Fibrosis Transmembrane Conductance Regulator's Nh₂-Terminal Nucleotide Binding Domain

Kim W. Chan, László Csanády, Donna Seto-Young, Angus C. Nairn, David C. Gadsby

J Gen Physiol (2000) 116 (2): 163–180.

DOI: https://doi.org/10.1085/jgp.116.2.163

Published: 17 July 2000

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Journal Articles

Cftr Channel Gating : Incremental Progress in Irreversible Steps

László Csanády, David C. Gadsby

J Gen Physiol (1999) 114 (1): 49–54.

DOI: https://doi.org/10.1085/jgp.114.1.49

Published: 01 July 1999

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NARROW

Optimization of CFTR gating through the evolution of its extracellular loops

Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel

CFTR gating: Invisible transitions made visible

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate

Structure–activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects

Catalyst-like modulation of transition states for CFTR channel opening and closing: New stimulation strategy exploits nonequilibrium gating

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2

Degenerate ABC composite site is stably glued together by trapped ATP

Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanisms

Four Ca²⁺ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate

Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains

Severed Molecules Functionally Define the Boundaries of the Cystic Fibrosis Transmembrane Conductance Regulator's Nh₂-Terminal Nucleotide Binding Domain

Cftr Channel Gating : Incremental Progress in Irreversible Steps

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